Navigating Tissue Chips from Development to Dissemination: A Pharmaceutical Industry PerspectiveThursday, 11 May 2017 at 14:30 Add to Calendar ▼SELECTBIOenquiries@selectbiosciences.com Microphysiological systems (best recognized as ‘organ chips’) are a rapidly developing in vitro technology that is providing unique opportunities to model the complexity of in vivo biology. The growing debate about the role of animal studies in a challenging rate of drug development attrition for both efficacy and safety has prompted excitement for the potential for greater clinical relevance of human-sourced microphysiological systems over traditional animal models. Attaining the full promise and impact of this innovation will take a very deliberate process of evolution. This presentation will outline a framework used at AstraZeneca to select the context of use for microphysiological systems and exemplify the type of data that is possible to achieve from such systems in drug development. Lastly, it will share an ongoing partnership between pharmaceutical industry scientists and NCATS that is facilitating the evolution of this technology. |