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SELECTBIO Conferences Clinical Applications of Stem Cells

Mari Dezawa's Biography

Mari Dezawa, Professor and Chair, Department of Stem Cell Biology and Histology & Department of Anatomy and Anthropology, Tohoku University

Prof. Mari Dezawa graduated Chiba University School of Medicine in 1989, awarded the degree of MD.
She worked as a resident in Department of Internal Medicine and Cardiology in Chiba University hospital for two years and then she got PhD degree in 1995. She became a research associate of Department of Anatomy in Chiba University Graduate School of Medicine where she started to clarify the mechanism of neural regeneration. She then moved to Department of Anatomy Yokohama City University as Assistant Professor in 2000 where she started to work with mesenchymal stem cells (MSCs). After moving to Kyoto University Graduate School of Medicine as Associate Professor in 2003, she discovered methods to induce neurons and skeletal muscle cells from human MSCs (J. Clin. Invest, 2004; Science, 2005).
In 2008, she became Professor and Chair of Department of Stem Cell Biology and Histology and Department of Anatomy and Anthropology in Tohoku University Graduate School of Medicine. Recently, she discovered a novel type of intrinsic human pluripotent stem cells which are named Muse cells that reside in normal adult mesenchymal tissues (PNAS, 2010, 2011).

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Discovery of Muse Cells shifts the Paradigm of Mesenchymal Stem Cells

Friday, 27 February 2015 at 11:20

Add to Calendar ▼2015-02-27 11:20:002015-02-27 12:20:00Europe/LondonDiscovery of Muse Cells shifts the Paradigm of Mesenchymal Stem CellsClinical Applications of Stem Cells in

We discovered non-tumorigenic pluripotent stem cells, Multilineage differentiating Stress Enduring (Muse) cells, that reside in the bone marrow and adipose tissue, and are collectable as SSEA-3(+) cells. They correspond to several percent of mesenchymal stem cells collected from these tissues. They are stress-tolerant, express pluripotency markers despite low telomerase activity, and are able to self-renew and generate cells of all three germ layers from a single cell. A highly useful feature of Muse cells is their specific ability to detect damage signals, which allows them to migrate toward and home into damaged tissues when infused into the peripheral blood stream where they can spontaneously differentiate into cells compatible with the homed-into tissue. These activities were confirmed in models of fulminant hepatitis, muscle degeneration, and skin injury. These effects are not recognized in remainder of mesenchymal cells, namely non-Muse cells. Thus, they are feasible for safe and efficient cell based-therapy.

Add to Calendar ▼2015-02-26 00:00:002015-02-27 00:00:00Europe/LondonClinical Applications of Stem CellsClinical Applications of Stem Cells in