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SELECTBIO Conferences Point-of-Care Diagnostics World Congress

Charlie Yeh's Biography

Charlie Yeh, , University Of California-Berkeley

Charlie is a PhD candidate in the Bioengineering Department at UC Berkeley. He did his BS degree in Engineering and System Sciences at National Tsing-Hua University in Taiwan. Charlie was also a visiting scholar at Tokyo Institute of Technology’s EE Department. His goal is to advance medical technologies that can have far-reaching social impact in underprivileged communities. Charlie was one of the original drafters of the Bill & Melinda Gates Foundation grant as well as the DARPA grant awarded to his research lab in 2011. Since then, he has been collaborating with these institutions to develop significantly cheaper quantitative diagnostic assays with microfluidic technology. He designs assays to be implemented in resource-poor settings that can replace costly centralized lab equipment. He aspires to transform his research into tangible products that can be widely disseminated and improve lives. Educated in Taiwan, Japan, and the U.S., Charlie is equipped with a broad international perspective to engage in global collaboration. It is his vision to promote next generation diagnostics technology with potential for large-scale social impact. He will be graduating with a doctorate degree from Berkeley by May 2015 and is currently seeking job opportunities in the microfluidics/diagnostics field.

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Vacuum Battery Pumping Integrated with Digital Plasma Separation for Quantitative Diagnostics

Friday, 19 September 2014 at 16:45

Add to Calendar ▼2014-09-19 16:45:002014-09-19 17:45:00Europe/LondonVacuum Battery Pumping Integrated with Digital Plasma Separation for Quantitative DiagnosticsPoint-of-Care Diagnostics World Congress in San Diego, California, USASan Diego, California,

Current blood-based quantitative nucleic acid (NA) detection requires many sample preparation steps or bulky and costly bench top equipment such as PCR machines. Here a portable, power-free, and significantly lower cost portable microfluidic platform for one-step quantitative NA detection is presented. This platform uses a next generation microfluidic pumping method, termed the “Vacuum Battery System”. Vacuum potential is pre-stored in a “vacuum battery” void, and discharged over gas permeable lung-like structures to drive flow. It enables dead-end and deep well loading, has excellent optical properties, and is not dependent on surface tension, all of which are common limitations of capillary pumping. Highly controlled pumping was possible for up to 2 hours (up to140 µl, range of 2~17 µl/min), without any external equipment, power sources, or pumps. Furthermore, it was possible to integrate plasma separation and sample compartmentalization (224 wells, 100 nl each) into one-step with the “Digital Plasma Separation” design in 12 minutes using inertial microfluidics. Lastly, this chip is able to perform on-chip end-point quantitative digital MRSA DNA detection directly from human whole blood within 30 mins, with a dynamic ranged of 10~105 copies DNA/ µl, using isothermal amplification (Recombinase Polymerase Amplification).

Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonPoint-of-Care Diagnostics World CongressPoint-of-Care Diagnostics World Congress in San Diego, California, USASan Diego, California,