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SELECTBIO Conferences Circulating Biomarkers World Congress 2017

Anastasia Khvorova's Biography

Anastasia Khvorova, Professor, RNA Therapeutics Institute, University of Massachusetts Medical School

Anastasia Khvorova, PhD, is Professor in the RNA Therapeutics Institute and the Program in Molecular Medicine at the University of Massachusetts Medical School (UMMS) in Worcester, Massachusetts. Before joining the UMMS faculty, she held leadership positions in industry, including Vice President of Research & Development and Chief Science Officer of Dharmacon, Founder and Scientific Advisor of Advirna, and Chief Science Officer and Senior Vice President of RXi Pharmaceuticals. Dr Khvorova’s industry experience in drug discovery and development collaborations with pharmaceutical companies along with her expertise in chemistry and cell biology allowed her to establish a lab at UMMS that brings together organic chemists and RNA biologists to develop novel approaches and solutions to understanding natural and therapeutic RNA trafficking and delivery. Dr Khvorova is a member of the Board of Directors of the Oligonucleotide Therapeutics Society and sits on the editorial board of Nucleic Acid Research. She is the author of more than 150 abstracts, more than 50 peer-reviewed articles, several book chapters, and more than 250 patents and patent applications; her publications are widely cited.

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Exosomes as Therapeutic RNA Delivery Vehicles

Monday, 20 March 2017 at 15:00

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Exosomes have the potential to act as “native" ONT delivery vehicles, but robust and scalable methods for loading therapeutic RNA cargo into exosomes are lacking. We show that hydrophobically modified siRNAs (hsiRNAs) efficiently load into exosomes upon co-incubation, without altering vesicle size, distribution, or integrity, and promote efficient neuronal internalization and Huntingtin mRNA silencing both in vitro and in vivo.

Add to Calendar ▼2017-03-20 00:00:002017-03-21 00:00:00Europe/LondonCirculating Biomarkers World Congress 2017Circulating Biomarkers World Congress 2017 in Boston, USABoston,