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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and Applications

Mei He's Biography

Mei He, Assistant Professor, University of Kansas and Chief Science Officer, Clara Biotech

Dr. He received her PhD degree at University of Alberta and completed her postdoctoral research training at University of California, Berkeley. From 2012 to 2013, she was a senior scientist studying early cancer diagnosis at the University of Kansas Medical Center/ Cancer Center. Currently, she is an assistant professor at University of Kansas. Her research expertise is centered on nano-scale integration of biomaterials and bioengineering approaches through Lab-on-Chip devices for cancer diagnosis, personalized medicine and global healthcare.

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Microfluidic On-Demand Harvesting of Therapeutic Exosomes

Wednesday, 4 October 2017 at 09:30

Add to Calendar ▼2017-10-04 09:30:002017-10-04 10:30:00Europe/LondonMicrofluidic On-Demand Harvesting of Therapeutic

The finding of exosomes opens new opportunities for developing nature, non-toxic therapeutic delivery systems. Exosomes play important biological roles via transferring selectively enriched proteins, RNAs, and mitochondrial DNA. The nano-sized exosomes are highly biocompatible with intrinsic payload and exhibit much stronger antigen loading flexibility, compared to other polymer nano-platforms. In spite of the significant roles in therapeutics and diagnostics, the study and development of the utility of exosomes is hampered by substantial technical difficulties in obtaining sufficient and pure immunogenic exosomes. Current production protocols (e.g, ultracentrifugation and filtration) are un-scalable, often labor-intensive and time-intensive, and in low-yield and purity (< 25%). In this work, we report a versatile, scalable microfluidic approach for processing exosomes with precise control and specificity, and on-demand harvesting. Current microfluidic exosome isolation approaches either handle limited quality of exosomes in microliter scale, or the processed exosomes are bound to solid surface/particles and unable to stay intact. We report continuous-flow, light-triggered on-demand harvesting of exosomes over milliliter scale of volumes. We foresee that microfluidic technology will provide game changer roles for exploring the utility of exosomes in therapeutics.

Add to Calendar ▼2017-10-02 00:00:002017-10-04 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and