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SELECTBIO Conferences Bioprinting and Bioink Innovations for 3D-Tissues

Michael Moore's Biography

Michael Moore, Professor of Biomedical Engineering, Tulane University and Co-Founder, AxoSim

Michael J. Moore, PhD, is a Professor of Biomedical Engineering in Tulane University's School of Science and Engineering. He is also the Co-Founder and Chief Science Officer of AxoSim, a creator of the Nerve-on-a-Chip platform that is developing disease models for neurogenerative diseases such as neurotoxicity, amyotrophic lateral sclerosis, and multiple sclerosis. His academic research focuses on developing in vitro models of neural growth, physiology, and disease by manipulating the chemical and physical extracellular microenvironment. Toward this end, his lab employs a number of microengineering technologies such as microscale tissue engineering, novel nanomaterials, digital light projection lithography, and bioprinting. Dr. Moore received his B.S. in Biological Systems Engineering from the University of Nebraska and his PhD in Biomedical Engineering from Mayo Clinic College of Medicine and Science. After postdoctoral research at the Massachusetts Institute of Technology and Schepens Eye Research Institute, he joined the faculty of the Department of Biomedical Engineering at Tulane University, where he has been since 2007. He and his wife Lisa and their three daughters live in the Broadmoor neighborhood near Tulane’s undergraduate campus in New Orleans, LA.

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Biofabrication of Neural Microphysiological Systems

Wednesday, 6 October 2021 at 13:30

Add to Calendar ▼2021-10-06 13:30:002021-10-06 14:30:00Europe/LondonBiofabrication of Neural Microphysiological SystemsBioprinting and Bioink Innovations for 3D-Tissues in Virtual Event - Eastern Daylight Time (EDT) ZoneVirtual Event - Eastern Daylight Time (EDT)

Microphysiological systems are being aggressively pursued as models of diseases for research and for screening drugs to better predict safety and efficacy on the path toward clinical trials. While a large number and wide variety of such systems abound, there has been relatively little progress toward the development of microphysiological models of peripheral nerve. This may be due in part because it is challenging to model the physiology of peripheral nerve in a manner that results can be interpreted in the context of human nerve function and/or disease. We have developed and reduced to commercial practice a 3D model of peripheral nerve in which axonal conduction is used as a primary functional metric, which is analogous to nerve conduction testing performed clinically. We have expanded on this recently to introduce a model of synaptic transmission from peripheral nerve to the dorsal spinal cord. This model may prove useful in the search for the next generation of pain-relieving drugs by being able measure effectiveness and parse mechanisms of different compounds without relying solely on behavioral studies in animals. As neural microphysiological models are increasingly pursued as viable commercial drug development strategies, scale-up of both fabrication and testing is rapidly becoming a major concern. We have begun to explore some unique biofabrication methods to begin to address this challenge.

Add to Calendar ▼2021-10-06 00:00:002021-10-06 00:00:00Europe/LondonBioprinting and Bioink Innovations for 3D-TissuesBioprinting and Bioink Innovations for 3D-Tissues in Virtual Event - Eastern Daylight Time (EDT) ZoneVirtual Event - Eastern Daylight Time (EDT)