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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Michael Moore's Biography

Michael Moore, Professor of Biomedical Engineering, Tulane University and Co-Founder, AxoSim

Michael J. Moore, PhD, is a Professor of Biomedical Engineering in Tulane University's School of Science and Engineering. He is also the Co-Founder and Chief Science Officer of AxoSim, a creator of the Nerve-on-a-Chip platform that is developing disease models for neurogenerative diseases such as neurotoxicity, amyotrophic lateral sclerosis, and multiple sclerosis. His academic research focuses on developing in vitro models of neural growth, physiology, and disease by manipulating the chemical and physical extracellular microenvironment. Toward this end, his lab employs a number of microengineering technologies such as microscale tissue engineering, novel nanomaterials, digital light projection lithography, and bioprinting. Dr. Moore received his B.S. in Biological Systems Engineering from the University of Nebraska and his PhD in Biomedical Engineering from Mayo Clinic College of Medicine and Science. After postdoctoral research at the Massachusetts Institute of Technology and Schepens Eye Research Institute, he joined the faculty of the Department of Biomedical Engineering at Tulane University, where he has been since 2007. He and his wife Lisa and their three daughters live in the Broadmoor neighborhood near Tulane’s undergraduate campus in New Orleans, LA.

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Peripheral Nerve-on-a-Chip: Quantifying Myelination and Demyelination

Wednesday, 6 June 2018 at 11:00

Add to Calendar ▼2018-06-06 11:00:002018-06-06 12:00:00Europe/LondonPeripheral Nerve-on-a-Chip: Quantifying Myelination and DemyelinationOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

Development of microphysiological models of the peripheral nervous system have lagged that of other organ systems. This is perhaps partially because peripheral nerve disorders are rarely life-threatening, though they are frequently severely debilitating. The most effective organ-on-a-chip models are those that reflect relevant anatomical and physiological features, enabling comparisons with animal studies or clinical outcomes. In our model of rat myelinated peripheral nerve, we show that we can quantify key measurements using histology and nerve conduction, exactly the main quantitative endpoints used in preclinical or clinical studies to assess peripheral nerve degeneration. In particular, we show that nerve conduction velocity correlates with myelin formation, as measured by % myelinated axons and g-ratio. In like manner, induced demyelination leads to structural degeneration and functional deficits that may also be quantified using histology and nerve conduction. This model is unique in its ability to capture these specific metrics of peripheral nerve health. Ongoing challenges and implications for modeling demyelinating disorders will also be discussed.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The