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SELECTBIO Conferences 3D-Models for Drug Testing: Organoids & Tissue Chips 2022

Rebecca Pompano's Biography

Rebecca Pompano, Associate Professor, Carter Immunology Center, University of Virginia

Dr. Rebecca Pompano is an Associate Professor in the Departments of Chemistry and Biomedical Engineering at the University of Virginia, and a member of the Beirne Carter Immunology Center and UVA Comprehensive Cancer Center. She earned her Bachelor’s degree in Chemistry at the University of Richmond in 2005 and a PhD in Bioanalytical Chemistry at the University of Chicago in 2011, and she conducted postdoctoral research in immunoengineering in the University of Chicago Dept. of Surgery from 2011-2014. Her laboratory develops cutting edge tools to unravel the complexity of the immune response, by applying microfluidics, bioanalytical chemistry, and biomaterials to fascinating immunological problems. In recognition of her laboratory’s work, she received numerous awards and fellowships including from The Hartwell Foundation, the Society of Analytical Chemists of Pittsburgh, the American Association of Immunologists, and the Cellular and Molecular Bioengineering Interest Group. She was named an Emerging Investigator by Lab on a Chip and Organs-on-a-Chip, and received the inaugural University of Virginia Research Excellence Award. She is the Co-Chair of the inaugural Gordon Research Conference for Immunoengineering (July, 2022) and the incoming Co-Chair for the 2023 International Symposium on Microscale Separations and Bioanalysis. In addition to her research, she is active in building inclusive environments for STEM research and education.

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Spatially Organized Microfluidic Models of the Lymph Node Ex Vivo

Tuesday, 13 September 2022 at 12:00

Add to Calendar ▼2022-09-13 12:00:002022-09-13 13:00:00Europe/LondonSpatially Organized Microfluidic Models of the Lymph Node Ex Vivo3D-Models for Drug Testing: Organoids and Tissue Chips 2022 in

Adaptive immunity begins in the lymph node, a small yet highly structured organ that has proven difficult to model with standard in vitro approaches.  The intricate spatial organization and dynamic nature of cell migration through this organ traditional interface-focused organ-on-chip models of limited use.  We have developed an approach that combines intact ex vivo slices of lymph node tissue with microfluidic fluid flow control, to begin to reproduce organ-level events in this fascinating tissue.  Tissue slices retain the spatial organization of the tissue and are readily adopted by biomedical research laboratories.  Using single-tissue cultures as well as multi-organ microfluidic cultures, we have established models of draining lymph node interactions with tumors and with vaccinated skin or muscle. Ultimately, these tools will be useful to visualize where, when, and how cells interact during immunity and inflammation, to reveal mechanisms of the immune response and inform the development of vaccines and immunotherapies.

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