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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Asia 2022

Amy Shen's Biography

Amy Shen, Professor, Okinawa Institute of Science and Technology Graduate University

Amy Shen is a professor at Okinawa Institute of Science and Technology Graduate University (OIST) in Japan, leading the Micro/Bio/Nanofluidics Unit since 2014. She was a faculty member in Mechanical Engineering at the University of Washington (USA) prior to moving to Japan. Amy's research is focused on microfluidics and lab-on-a-chip devices at the bio/nano-interface, with applications in biotechnology. She is a Fellow of the American Physical Society and the Royal Society of Chemistry. Amy has won numerous awards including the NSF CAREER Award and the Ralph E. Powe Junior Faculty Enhancement Award. Amy was also a Fulbright Scholar in 2013. She is an associate editor for Soft Matter and serves on the editorial advisory board for ACS Sensors, Journal of Rheology, and Physics of Fluids.

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Nanoplasmonic Platforms for COVID-19 Vaccine Development

Thursday, 6 October 2022 at 11:30

Add to Calendar ▼2022-10-06 11:30:002022-10-06 12:30:00Europe/LondonNanoplasmonic Platforms for COVID-19 Vaccine DevelopmentLab-on-a-Chip and Microfluidics Asia 2022 in Tokyo, JapanTokyo,

The recent emerging SARS-CoV-2 variants require swift actions in identifying specific antigens and optimizing vaccine development to maximize the humoral response of the patient. Specifically, measuring the specificity and the amount of antibody produced by the host immune system with high throughput and accuracy is crucial to develop timely diagnostics and therapeutic strategies. Motivated by finding an easy-to-use and cost-effective alternative to existing serological methodologies, an optomicrofluidic sensing platform is developed to rapidly detect antibodies against the SARS-CoV-2 spike protein in diluted human plasma within 30 minutes, at the limit of detection of 0.5 pM (0.08 ng/mL). The sensing principle is based on localized surface plasmon resonance (LSPR) involving gold nanospikes (fabricated by electrodeposition) in a microfluidic device, coupled with an optical probe. Extending this work, a nanoplasmonic multiplex optical biosensor to capture the humoral response in serums against Spike from SARS-CoV-2 and two hemagglutinins (HAs) from influenza viruses is established recently. This multiplex assay demonstrates multiple serum antibody profiling by using immunized mice, validated by the ELISA. Our nanofabrication and surface patterning techniques, combined with biotin tag-based protein functionalization method, can be utilized to establish high throughput screening platform for the SARS-CoV-2 vaccine development and beyond.

Add to Calendar ▼2022-10-06 00:00:002022-10-07 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Asia 2022Lab-on-a-Chip and Microfluidics Asia 2022 in Tokyo, JapanTokyo,