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SELECTBIO Conferences Organs-on-Chips and 3D-Cultures: Technologies and Approaches

Maria Carla Parrini's Biography

Maria Carla Parrini, Senior Research Engineer, Institut Curie

Maria Carla Parrini is a cell biologist expert in cell signal transduction, cell motility/invasion and advanced imaging of living cells. After a PhD degree in Biochemistry at University Paris-Orsay, she was post-doc researcher at Harvard Medical School (Boston, USA) (1997-2002) and at Osaka University (Japan) (2002-2003). She works since 2003 at Institut Curie (Paris, France). Her current research focus is the development and application of novel technologies at the frontier between Biology and Physics, in order to place the oncogenic transduction signaling networks inside the spatial-temporal dimension of the cells, in the context of the tumor ecosystems.

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Reconstitution and Visualization of Tumors-on-Chip for Precision Medicine

Friday, 8 July 2016 at 15:00

Add to Calendar ▼2016-07-08 15:00:002016-07-08 16:00:00Europe/LondonReconstitution and Visualization of Tumors-on-Chip for Precision

Tumor microenvironments are ecosystems composed of a variety of cell types positioned in complex physicochemical contexts. We generated microfluidic devices in which highly-controlled cell co-cultures reconstituted a breast tumor ecosystem (Her2+ sub-type), containing cancer cells, cancer-associated fibroblasts, endothelial cells, and immune cells. We succeeded in recapitulating on these tumors-on-chip the immune-dependent systemic response to a drug used in clinic, the Trastuzumab monoclonal antibody (Herceptin®). This approach provides a novel experimental system to understand the complex effects of Trastuzumab on the tumor microenvironment and, very importantly, to investigate its resistance mechanisms. We are currently working toward the personalization of these tumors-on-chip by the introduction of patient-derived cells in the perspective of personalized diagnostic and precision medicine.

Add to Calendar ▼2016-07-07 00:00:002016-07-08 00:00:00Europe/LondonOrgans-on-Chips and 3D-Cultures: Technologies and