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SELECTBIO Conferences Biodetection & Biosensors 2017

Karolien De Wael's Biography

Karolien De Wael, Full Professor, Antwerp University

Prof. Dr. Karolien De Wael obtained her PhD in Chemistry at Ghent University in 2005 in the field of electrochemistry. In 2011, she was appointed as Research Professor and since 2018 she is full professor at the University of Antwerp in Belgium. She is group leader of the A-Sense Lab at the University of Antwerp (ca 25 members). Our lab is part of the Bioscience Engineering Department and performs fundamental, methodological and application-oriented research involving a wide range of analytical techniques.

Today the demand for ultra-sensitive and selective (on-site/in process) detection systems resounds from the health, food and environmental sector. These systems must be able to detect and quantify target molecules, important in point-of-care testing and for assessing the level of contamination in food, industrial and environmental samples. (Photo)Electrochemistry is an inviting approach for monitoring the presence and concentration of pollutants as these devices are fast, portable and extremely sensitive and selective towards (non)electro-active species. A strategic vision of K. De Wael aims at a portfolio of sensor technologies that can be applied in different markets/sectors embracing the idea of responsible research and innovation.

K. De Wael coordinates the EU BorderSens project. BorderSens offers beyond state of the art solutions to facilitate fast identification of illicit drugs greatly reducing false negative and false positive results. In this lecture, a novel sensing technology for cancer research will be presented. A-Sense Lab is both embedded in the Enviromics consortium (Industrial Research Fund) and Nanolab Center of Excellence within the University of Antwerp.

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Singlet Oxygen-based Electrosensing

Tuesday, 10 October 2017 at 15:15

Add to Calendar ▼2017-10-10 15:15:002017-10-10 16:15:00Europe/LondonSinglet Oxygen-based ElectrosensingBiodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge,

It is well known that phenolic compounds and, particularly, hydroquinone can shuttle electrons between horse radish peroxidase (HRP) and an electrode, which allows the bioelectrocatalytical reduction of H2O2 by the enzyme. When a phenolic compound shuttles the electrons, it passes through many cycles of oxidation and electrochemical reduction (regeneration) near the electrode. Such mechanism enhances the electrochemical response of the compound and has been employed for the electrochemical detection of phenols and their derivatives. However, H2O2 as an oxidant must be introduced into the system, which is an obvious limitation of the method. Our solution is to replace the enzyme with a photosensitizer which produces reactive oxygen species and can catalyze the oxidation of a compound of interest by O2 that is naturally present in the measuring conditions. Here we used a fluorinated phthalocyanine complex of Zn which is capable to form singlet oxygen under red light illumination (? ca. 650 nm).

Add to Calendar ▼2017-10-10 00:00:002017-10-11 00:00:00Europe/LondonBiodetection and Biosensors 2017Biodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge,