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SELECTBIO Conferences Clinical Translation of Organoids and Organs-on-Chips 2022

Yan Yan Shery Huang's Biography

Yan Yan Shery Huang, Professor of BioEngineering, University of Cambridge

Dr. Huang is Professor of BioEngineering, University of Cambridge. She completed her MEng degree in Materials Science and Engineering from Imperial College London in 2007. She then pursued a PhD in Physics at Cambridge. She was a visiting researcher at University of Texas at Austin (2008), and an Oppenheimer Fellow and a Homerton College Junior Research Fellow (2011-2013). She is a recipient of the prestigious ERC Starting grant, and a fellow of the Institute of Fellow of the Institute of Materials, Minerals and Mining, UK.

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Cellular Dynamics and ‘MOrPF-genesis’ in Biofabrication and Bioprinting

Tuesday, 22 March 2022 at 15:00

Add to Calendar ▼2022-03-22 15:00:002022-03-22 16:00:00Europe/LondonCellular Dynamics and ‘MOrPF-genesis’ in Biofabrication and BioprintingClinical Translation of Organoids and Organs-on-Chips 2022 in

Dynamic and time-dependent processes are inherent in living matters. With the aim to fabricate advanced biological systems and products, it is important to consider how cells dynamically interact with their ‘biofabrication’ protocol and environment. This talk will focus on three example cases. First, it will present process visualization of cell extrusion deposition through a high-resolution nozzle. In this context, we observed the motions of cells were overwhelmed by cellular re-organization events in a nozzle, including aggregation and sedimentation. Thus, the cells do not follow the flow paths purely driven by a laminar fluid flow within a narrow tip. In the second example, the talk will present how cells could dynamically adjust their shapes during migration, in response to different microfibre patterns from straight to curly. Key morphological features such as the variation of cells’ minor axis were identified for understanding cell migration in fibril matrices. In the third example, it will present how integrating self-assembly and biofabrication could lead an organoid engineering approach termed Multi-Organoid Patterning and Fusion (MOrPF). MOrPF is used to assemble scaffold-free macroscale airway tubes, leading to flowable organoid-on-a-chip, and branching tubular structures. Together, our studies might provide guiding principles for optimizing biofabrication processes of cell-laden constructs.

Add to Calendar ▼2022-03-21 00:00:002022-03-22 00:00:00Europe/LondonClinical Translation of Organoids and Organs-on-Chips 2022Clinical Translation of Organoids and Organs-on-Chips 2022 in