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SELECTBIO Conferences Biodetection & Biosensors 2017

Marloes Peeters's Biography

Marloes Peeters, Lecturer, Manchester Metropolitan University

Marloes Peeters graduated from Eindhoven University of Technology (the Netherlands) with a degree in Chemistry & Chemical Engineering. For her PhD, she moved to research institute IMO/IMOMEC in Belgium where she was a member of the BIOSensors group of prof. Wagner. Part of her research involved the synthesis of synthetic polymeric receptors, while the other part was related to the detection of biomolecules. After finishing her PhD, she continued as a postdoctoral researcher within the same group to develop a novel thermal detection method for measurements of both small molecules and proteins in complex matrices (for instance, human blood plasma or saliva). In 2014, she started working at the organic chemistry group at Queen Mary University of London in order to get experience with ‘natural’ receptors, in this case enzymes. Since mid 2015, she moved to her current position as a lecturer in Chemical Biology at Manchester Metropolitan University. She currently has four postgraduate students that are all working on biosensor related projects, pubished >25 papers on Molecularly imprinted Polymers and has 4 patents in thermal biosensing.

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Use of Synthetic Recognition Elements for the Thermal Sensing of Biomarkers

Wednesday, 11 October 2017 at 16:15

Add to Calendar ▼2017-10-11 16:15:002017-10-11 17:15:00Europe/LondonUse of Synthetic Recognition Elements for the Thermal Sensing of BiomarkersBiodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge,

Molecular Imprinted Polymers (MIPs) are synthetic receptors with recognition sites that are complementary to the template in their size, shape, and orientation of functional groups . These microparticles are synthesized for the neurotransmitter noradrenaline with the optimal composition and binding conditions being determined via optical batch rebinding experiments. Next, the obtained MIPs are mixed within screen-printed inks to produce mass-producible bulk modified MIPs screen-printed electrodes (MIP-SPEs). In this contribution, the supporting surface which the MIP-SPEs are screen-printed upon are explored to deviate from conventional polyester, to polyvinylchloride, tracing paper and household-printing paper. The performance of the MIP-SPEs are measured using the Heat-Transfer Method (HTM), a straightforward and low-cost detection technique based on thermal resistance. At first, the noise on the signal is minimized by adjusting the settings of the temperature feedback loop. Second, the response of the MIP-SPEs to noradrenaline is measured and compared for the different substrate materials. Sensors printed onto paper are considered in further experiments as their response to noradrenaline is the highest and advantageous material properties, including sustainability and flexibility of the material. Subsequently, dose-response curves are determined by simultaneously measuring HTM and Thermal Wave Transport Analysis (TWTA). The latter is a new thermal detection method that relies on the use of thermal waves and has the advantage of a short measurement time (2 min). With these thermal methods, it is possible to specifically detect noradrenaline in aqueous solutions and quantify it at relevant concentrations. In summary, by combining synthetic receptors with thermal measurement techniques it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules. Through exploring novel SPE substrates, a system is designed that is flexible and holds potential for the use in commercial biomedical devices and complex sensor architectures.

Add to Calendar ▼2017-10-10 00:00:002017-10-11 00:00:00Europe/LondonBiodetection and Biosensors 2017Biodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge,