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SELECTBIO Conferences Point-of-Care, Biosensors & Mobile Diagnostics Europe 2019

Marloes Peeters's Biography



Marloes Peeters, Lecturer, Manchester Metropolitan University

Marloes Peeters graduated from Eindhoven University of Technology (the Netherlands) with a degree in Chemistry & Chemical Engineering. For her PhD, she moved to research institute IMO/IMOMEC in Belgium where she was a member of the BIOSensors group of prof. Wagner. Part of her research involved the synthesis of synthetic polymeric receptors, while the other part was related to the detection of biomolecules. After finishing her PhD, she continued as a postdoctoral researcher within the same group to develop a novel thermal detection method for measurements of both small molecules and proteins in complex matrices (for instance, human blood plasma or saliva). In 2014, she started working at the organic chemistry group at Queen Mary University of London in order to get experience with ‘natural’ receptors, in this case enzymes. Since mid 2015, she moved to her current position as a lecturer in Chemical Biology at Manchester Metropolitan University. She currently has four postgraduate students that are all working on biosensor related projects, pubished >25 papers on Molecularly imprinted Polymers and has 4 patents in thermal biosensing.

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Smart Thermometers: Screening for Biomarkers Using Molecularly Imprinted Polymers (MIPs) Combined with Thermal Detection

Wednesday, 19 June 2019 at 10:00

Add to Calendar ▼2019-06-19 10:00:002019-06-19 11:00:00Europe/LondonSmart Thermometers: Screening for Biomarkers Using Molecularly Imprinted Polymers (MIPs) Combined with Thermal DetectionPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Molecularly Imprinted Polymers (MIPs) are synthetic antibody mimics: similar to antibodies they possess high affinity for a chosen template molecule. However, they have distinct advantages over their natural counterparts such as low-cost, superior chemical and thermal stability, and straightforward production process. In this contribution, we will discuss the use of nanoMIPs that are synthesized via a solid-phase approach. The high affinity nanoparticles prepared by this technique are water-soluble, meaning it is simple to directly functionalize them onto thermocouples via dipcoating. These functionalized thermocouples were subsequently inserted into a home-made heat-transfer device that measures the temperature of the liquid in a flow cell. It was shown that binding of the target to the MIP layer increased the resistance at the solid-liquid interface, leading to a lower temperature being recorded by the functionalized thermocouple. With this method, it was possible to measure various compounds, ranging from small targets such as the antibiotic vancomycin to larger biomarkers such as troponin, in the low nanomolar regime in buffered solutions. The sensitivity was significantly enhanced by using standard EDC coupling to covalently attach the nanoparticles to the surface, allowing to control the surface architecture. Finally, the design of the current flow cell was adjusted to incorporate four thermocouples, demonstrating the first multiplex format of this sensor platform. In this presentation, a case study on the detection of cardiac biomarkers, including troponin, will be discussed.


Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonPoint-of-Care, Biosensors and Mobile Diagnostics Europe 2019Point-of-Care, Biosensors and Mobile Diagnostics Europe 2019 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com