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SELECTBIO Conferences Organ-on-a-Chip & Tissue-on-a-Chip Europe 2019

Andries D. van der Meer's Biography

Andries D. van der Meer, Associate Professor, Scientific lead, Organ-on-Chip Center Twente, University of Twente

Dr. Andries D. van der Meer is Associate Professor at the Faculty of Science and Technology of the University of Twente, The Netherlands. He is leader of the research theme ‘Organs-on-Chips’ in the Applied Stem Cell Technologies group of the Bioengineering Technologies cluster, supervising five Ph.D. candidates and coordinating multiple research projects on the development of blood vessels-on-chips as well as their integration in full organ-on-chip systems like the retina-on-chip, lung-on-chip and heart-on-chip.

From 2013 to 2015, Dr. Van der Meer worked as a Senior Research Fellow at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering of Harvard University, Cambridge, MA, USA. He actively developed organ-on-chip models of the blood-brain barrier and the alveolus for the Defense Advanced Research Projects Agency (DARPA) Microphysiological Systems program and coordinated a collaborative project between the Wyss Institute organ-on-chip start-up company Emulate, Inc. and Janssen Pharmaceuticals. Before joining Harvard University, he was a Post-Doctoral Fellow at Prof. Albert van den Berg’s BIOS/Lab-on-a-Chip group of the University of Twente, The Netherlands. During that time, he also served as an Assistant Coordinator for the project ‘Beyond Borders: Organs-on-Chips’ of the Dutch Royal Academy (KNAW). This project led to the founding of the Dutch Human Organ and Disease Model Technologies (hDMT) Organ-on-Chip consortium, for which Dr. Van der Meer is his university’s representative.

Dr. Van der Meer obtained his Ph.D. in Biomedical Engineering from the University of Twente, The Netherlands in 2010, and received his M.Sc. degree in Medical Biology from the University of Groningen, The Netherlands in 2005.

Andries D. van der Meer Image

Three-Dimensional Blood Vessels-on-Chips: Perfusion With Blood and Integration Into Organs-on-Chips

Tuesday, 18 June 2019 at 14:45

Add to Calendar ▼2019-06-18 14:45:002019-06-18 15:45:00Europe/LondonThree-Dimensional Blood Vessels-on-Chips: Perfusion With Blood and Integration Into Organs-on-ChipsOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The

Small blood vessel dysfunction associated with chronic inflammation and oxidative stress is increasingly recognized as a key aspect of a wide array of diseases, such as heart failure with preserved ejection fraction, diabetic retinopathy and cerebral small vessel disease. Advanced in vitro models of small diameter blood vessels will become essential in understanding the pathophysiology of these diseases as well as in finding new strategies for prevention and treatment. Here, three-dimensional microfluidic models of small-diameter blood vessels or ‘blood vessels-on-chips’ are presented, which integrate (1) human vascular tissue, including human induced pluripotent stem cell-derived cells, (2) controlled flow patterns, and (3) human whole blood. Examples are given of how these blood vessels-on-chips can be used to study relevant parameters of vascular function and dysfunction, like cytokine release, platelet adhesion and permeability. Moreover, it is shown how blood vessels-on-chips can be integrated in more complex organs-on-chips like heart-on-chip and retina-on-chip models to study vascular dysfunction in more comprehensive disease models.

Add to Calendar ▼2019-06-18 00:00:002019-06-19 00:00:00Europe/LondonOrgan-on-a-Chip and Tissue-on-a-Chip Europe 2019Organ-on-a-Chip and Tissue-on-a-Chip Europe 2019 in Rotterdam, The NetherlandsRotterdam, The