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SELECTBIO Conferences Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018

Nikolce Gjorevski's Biography

Nikolce Gjorevski, Scientist, Mechanistic Safety, Pharmaceutical Sciences, Roche Innovation Center Basel

After receiving an undergraduate degree in chemical engineering at Lafayette College, I enrolled in the graduate chemical and biological engineering program at Princeton University. Mentored by Celeste Nelson, I used novel tissue microfabrication approaches to study mammary gland development and disease quantitatively. After completing my PhD at Princeton, I received an EMBO Long-Term Postdoctoral Fellowship to carry out postdoctoral work, in the group of Matthias Lutolf at EPFL. In Lausanne, I used modular synthetic hydrogels to dissect the regulation of intestinal stem cell fate by the ECM, and designed well-defined alternatives to natural matrices for the culture of epithelial stem cells and organoids. I began a Scientist position at Roche in 2018, joining the company’s effort to establish advanced cellular models and microphysiological systems as platforms for drug discovery.

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Advanced in vitro Cellular Systems as Platforms for Drug Development

Wednesday, 6 June 2018 at 08:30

Add to Calendar ▼2018-06-06 08:30:002018-06-06 09:30:00Europe/LondonAdvanced in vitro Cellular Systems as Platforms for Drug DevelopmentOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The

Epithelial organoids are miniature versions of real organs formed by stem cell self-organization.  In combination with Organs-on-a-chip approaches, organoids are promising models of organ development, function and disease, with potential applications in basic research, drug discovery and cell-based therapies. However, their research impact is currently held back by a number of limitations, including dependence on ill-defined matrices, heterogeneity and irreproducibility, and closed, inside-out epithelial structure. We will discuss these caveats, and propose strategies to overcome them, thereby expanding the applicability of organoids as superior in vitro models of organ physiology and disease.

Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The