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SELECTBIO Conferences Point-of-Care, Biosensors and Rapid Dx Europe 2024

Cesar Pascual García's Biography

Cesar Pascual García, Lead Research Scientist, Luxembourg Institute of Science and Technology

César Pascual García is Coordinator and Principal investigator of research projects and also Core-Tech line manager at the Luxembourg Institute for Science and Technology for materials MedTech for personalized medicines. His study focuses developing lab on a chip devices to detect, synthesize, modify, and decompose the DNA and proteins using microchip technology to function alongside biology. He is currently the project coordinator for ELECTROMED, a FET-OPEN project sponsored by the European Innovation Council to build a cancer vaccine-screening platform, based on FET-sensors with programable peptide sequences. He was recently appointed as the European Innovation Council's ambassador until 2027.

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ElectroMed – A Programmable Peptide/Protein Screening Platform for Immunology

Tuesday, 25 June 2024 at 17:00

Add to Calendar ▼2024-06-25 17:00:002024-06-25 18:00:00Europe/LondonElectroMed – A Programmable Peptide/Protein Screening Platform for ImmunologyPoint-of-Care, Biosensors and Rapid Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

Immunology has advanced significantly in recent years thanks to a better knowledge of molecular protein recognition, which has allowed for the creation of innovative treatment options such as genetic vaccines and cell therapies. However, there is a need to accelerate the process of epitope recognition by proteins in order to generate personalized therapies. ElectroMed has been a project with six European partners in which we created a concept for a programmable peptide screening platform based on an array of Immuno-FET sensors with programmable peptide receptors synthesized in-situ using electrochemically generated acid.

A proof-of-concept has been demonstrated by controlling the deprotection of acid labile groups, which enables a high purity synthesis of crude peptides. We remove diffusion-limited processes in chemistry by automating the peptide synthesis and using microfluidic flow in-situ synthesis in planar sensors, allowing us to expedite time to results. FET sensors have the potential to provide online quality control of peptide synthesis by detecting the fingerprints of acid labile group protection and deprotection, as well as superior information quality because label-free sensors can provide kinetic information.

In conclusion, our approach has the potential to speed research into peptide protein screening of linear peptide sequences. In this talk we will review our results and provide the context for the applications in immunology.

Add to Calendar ▼2024-06-24 00:00:002024-06-25 00:00:00Europe/LondonPoint-of-Care, Biosensors and Rapid Dx Europe 2024Point-of-Care, Biosensors and Rapid Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The