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SELECTBIO Conferences Bioengineering for Building Microphysiological Systems 2022

Regina Luttge's Biography

Regina Luttge, Professor, Eindhoven University of Technology

Regina Luttge investigates and develops microsystems for medicine and biology applying emerging and established micro-nanofabrication methods to control systems’ properties at the nanoscale. Regina studied Applied Sciences in Germany and worked as an engineering researcher at Institut für Mikrotechnik Mainz (IMM GmbH) for nearly five years prior to starting her PhD studies in Microsystems Technologies at Imperial College, London, in 1999. In 2003 she received her PhD from the University of London on the development of fabrication technologies for micro-optical scanners. Switching her research interest to microfluidic systems, Luttge went on to work at the University of Twente’s MESA+ Institute for Nanotechnology, The Netherlands. Initially as a postdoc and later, when she received a Veni award by The Netherlands Organisation for Scientific Research (NWO) as an Assistant Professor in the Mesoscale Chemical Systems group. Receiving her second personal award (ERC Starting grant) by the European Research Council in 2011 empowered her to set up her own research line in microsystems for medicine and biology as an independent PI. In 2013, she moved her research line to the newly started Microsystems section at TU/e, where she was also appointed Associate Professor in the same year. Since 2018, she continuous her research activities within in the Microsystems section as Chair of Neuro-Nanoscale Engineering. Currently, she is the leader of CONNECT, a 5 years EU funded project conducting research to better understand Parkinson’s disease by means of Organ-on-a-Chip (OOC), specific microsystems recapitulating the in vivo microenvironment of human tissues in a dish. Besides education and research, Regina is passionate about spinning off new businesses from her academic activities, encouraging her students at all levels of their educational program to take part in the innovation chain.

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Nervous System-on-a-Chip: Closing the Knowledge Gap Between in vitro and in vivo Experiments

Monday, 24 October 2022 at 09:45

Add to Calendar ▼2022-10-24 09:45:002022-10-24 10:45:00Europe/LondonNervous System-on-a-Chip: Closing the Knowledge Gap Between in vitro and in vivo ExperimentsBioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The

Many advances in in vitro technologies to study brain cell cultures have been made by means of microfluidic Brain-on-a-Chips. However, the development of Brain-on-Chips primarily focus on the implementation of cortical cells from human stem cell source in a 3D cultured microenvironment. Instead, the objective of our EU project CONNECT is to mimic the in vivo functions of the nervous system in one connected chip system. Hence, the project brings together the knowledge accumulated among neuroscientists, stem cell experts and engineers to investigate the origins and possible treatments for Parkinson's disease in an extension of the brain-on-chip model, called nervous system-on-chip, linking tissue of the central nervous system and the enteric nervous system. In this presentation, we discuss the importance of instructive micromechanical cues next to the complexity of culture conditions in nervous system on a chip that can be simplified by selecting scaffolding materials containing instructive physical cues by design rather than ill-defined and poorly controllable biological matrices. Finally, we pinpoint on the importance to correlate findings in vitro with observations to be correlated with results from in vivo modeling.

Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonBioengineering for Building Microphysiological Systems 2022Bioengineering for Building Microphysiological Systems 2022 in Rotterdam, The NetherlandsRotterdam, The