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SELECTBIO Conferences Flow Chemistry Congress 2018

Hélène Lebel's Biography

Hélène Lebel, Professor, Department of Chemistry, University of Montreal

Hélène Lebel received her PhD from Université de Montréal under the supervision of Prof. André B. Charette in 1998. She then joined the group of Eric N. Jacobsen at Harvard University as a NSERC Postdoctoral Fellow. She began her independent academic career at the Université de Montréal as an assistant professor in 1999, under a NSERC University Faculty Award. She was promoted to the rank of Associate Professor in 2005, and Full Professor in 2010. The quality of her research has been recognized with many awards, including the Enantioselective Synthetic Chemistry Research Award in 2005, the Johnson & Johnson Focused Funding Grant Award in 2008, the Merck Frosst Centre for Therapeutic Research Award in 2009 and the Clara Benson Award in 2014. She held the Canada Research Chair in Organometallic Catalysis (Tier II) from 2006 to 2016. She is now the author of 60 publications as an independent researcher and has contributed to numerous book chapters. Her research program addresses the development of novel catalytic green processes and the discovery of recyclable reagents. More recently she devoted part of her research program to the development of novel, innovative continuous flow processes.

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New Continuous Flow Synthetic Methods with Highly Reactive Intermediates

Monday, 12 November 2018 at 15:45

Add to Calendar ▼2018-11-12 15:45:002018-11-12 16:45:00Europe/LondonNew Continuous Flow Synthetic Methods with Highly Reactive IntermediatesFlow Chemistry Congress 2018 in Miami, FloridaMiami,

Continuous flow technology offers many advantages, including the safe manipulation of highly reactive intermediates.  As such, a number of methods for the preparation and the use of diazo reagents in continuous flow have been described in the literature. Another class of highly reaction intermediates that benefit from continuous flow technology are aliphatic diazonium intermediates. The Lebel group has shown that aliphatic diazoniums can be in-situ generated from an amine and a nitrite reagent in the presence of an acid. The reaction conditions are compatible with a large variety of functional groups. The trapping of aliphatic diazoniums with carboxylates, electron rich aromatics and other nucleophiles afforded various synthetic compounds in high yields.  The optimization details and the scope of this methods will be described in this presentation.

Add to Calendar ▼2018-11-12 00:00:002018-11-13 00:00:00Europe/LondonFlow Chemistry Congress 2018Flow Chemistry Congress 2018 in Miami, FloridaMiami,