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SELECTBIO Conferences Extracellular Vesicles 2022: Biology, Disease & Medicine

Steven C. George's Biography

Steven C. George, Professor and Chair, Department of Biomedical Engineering, University of California-Davis

Steven C. George, M.D., Ph.D. is a Professor of Biomedical Engineering at the University of California, Davis. He received his bachelors degree in chemical engineering in 1987 from Northwestern University, M.D. from the University of Missouri School of Medicine in 1991, and Ph.D. from the University of Washington in chemical engineering in 1995. He was on the faculty at the University of California, Irvine for 19 years (1995-2014) where he pursued a range of research interests including pulmonary gas exchange, lung mechanics, vascularizing engineered tissues, and microphysiological systems. The NIH FIRST award in 1998 and the CAREER and Presidential Early Career Award for Scientists and Engineers (PECASE) from the National Science Foundation in 1999 have previously recognized his work. While at UCI, he served as the William J. Link Professor and founding Chair of the Department of Biomedical Engineering (2002-2009), the Director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology (2009-2014), and was the PI on a T32 predoctoral training grant from the National Heart Lung and Blood Institute. In 2014 he transitioned to become the Elvera and William Stuckenberg Professor and Chair of Biomedical Engineering at Washington University in St. Louis, and in 2017 moved to the UC Davis. He was elected a fellow in the American Institute of Medical and Biological Engineering (AIMBE) in 2007, a fellow of the Biomedical Engineering Society in 2017, has published more than 140 peer-reviewed manuscripts, and co-founded two early start-up companies. His work is currently funded by grants from the NIH that focus on creating tissue engineered models of the cardiac, pancreas, bone marrow, and cancer microenvironments using induced pluripotent stem cell and microfabrication technology.

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Convective Transport and Binding of Extracellular Vesicles Establish Biologically Relevant Spatial Gradients

Wednesday, 14 September 2022 at 11:00

Add to Calendar ▼2022-09-14 11:00:002022-09-14 12:00:00Europe/LondonConvective Transport and Binding of Extracellular Vesicles Establish Biologically Relevant Spatial GradientsExtracellular Vesicles 2022: Biology, Disease and Medicine in

Extracellular vesicles (EVs) are small (50-150 nm diameter) composite particles secreted by cells and comprised of a lipid-based membrane surrounding an aqueous core.  The membrane and core can each incorporate a wide range of molecules (e.g., proteins, nucleic acids) that can impact cellular function; thus, EVs can impact in vivo biology, but have also generated significant excitement for their potential theranostic (therapeutic and diagnostic) applications in cancer. How EVs are transported (convection, diffusion, and binding) within the extracellular space is poorly understood.  We hypothesized that EVs are transported predominantly by convection through the interstitium and could establish a spatial gradient via binding to laminin through integrins alph3beta1 and alpha6beta1 expressed on their surface. Our early experimental studies demonstrate EV binding to a laminin-rich extracellular matrix (ECM) increases as the malignant potential of the cellular source increases (MCF10A, MCF10DCIS, MCF10CA1). Binding of the EV to the ECM generates an observable spatial gradient, which impacts the migration of M2-like differentiated macrophages.  The magnitude of the gradient is partially abrogated by blocking antibodies to alpha3beta1 and alpha6beta1 integrin subunits. Examination of EV interstitial transport will enhance our understanding of the dynamic tumor microenvironment and could present new targets for early-stage disease.

Add to Calendar ▼2022-09-13 00:00:002022-09-14 00:00:00Europe/LondonExtracellular Vesicles 2022: Biology, Disease and MedicineExtracellular Vesicles 2022: Biology, Disease and Medicine in