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SELECTBIO Conferences Organoids & Organs-on-Chips 2021

Steven C. George's Biography

Steven C. George, Professor and Chair, Department of Biomedical Engineering, University of California-Davis

Steven C. George, M.D., Ph.D. is a Professor of Biomedical Engineering at the University of California, Davis. He received his bachelors degree in chemical engineering in 1987 from Northwestern University, M.D. from the University of Missouri School of Medicine in 1991, and Ph.D. from the University of Washington in chemical engineering in 1995. He was on the faculty at the University of California, Irvine for 19 years (1995-2014) where he pursued a range of research interests including pulmonary gas exchange, lung mechanics, vascularizing engineered tissues, and microphysiological systems. The NIH FIRST award in 1998 and the CAREER and Presidential Early Career Award for Scientists and Engineers (PECASE) from the National Science Foundation in 1999 have previously recognized his work. While at UCI, he served as the William J. Link Professor and founding Chair of the Department of Biomedical Engineering (2002-2009), the Director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology (2009-2014), and was the PI on a T32 predoctoral training grant from the National Heart Lung and Blood Institute. In 2014 he transitioned to become the Elvera and William Stuckenberg Professor and Chair of Biomedical Engineering at Washington University in St. Louis, and in 2017 moved to the UC Davis. He was elected a fellow in the American Institute of Medical and Biological Engineering (AIMBE) in 2007, a fellow of the Biomedical Engineering Society in 2017, has published more than 140 peer-reviewed manuscripts, and co-founded two early start-up companies. His work is currently funded by grants from the NIH that focus on creating tissue engineered models of the cardiac, pancreas, bone marrow, and cancer microenvironments using induced pluripotent stem cell and microfabrication technology.

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Using Microfluidics for Immune Cell Trafficking and Capture

Wednesday, 15 December 2021 at 10:00

Add to Calendar ▼2021-12-15 10:00:002021-12-15 11:00:00Europe/LondonUsing Microfluidics for Immune Cell Trafficking and CaptureOrganoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island,

Microfluidic technology has played a leading role to advance our understanding of fundamental biological processes including cell separation and isolation, next generation sequencing, and cell trafficking.  Over the past five years our lab has applied the basic principles of microfluidics to control fluid shear and flow to create simple microphysiological systems to better understand:  1) how to capture and isolate rare immune cells from the peripheral circulation, and 2) the principles which guide and control immune cell (lymphocytes, monocytes, and neutrophils) trafficking in complex tissue microenvironments.  For the former, we leverage the ability to coat surfaces with antigens that are recognized by rare populations of B lymphocytes in the peripheral circulation.  We then control the shear force at the surface and can capture and isolate these rare cell populations.  Understanding how these rare cell populations evolve over time following viral (e.g., SARS-CoV-2, influenza) infection is central to understanding immunity following infection or immunization. For the latter, we are pursuing three projects.  The first involves neutrophil trafficking into the cardiac muscle during COVID19-induced “cytokine storm”, including counterstrategies that limit binding of neutrophils to the inflamed endothelium.  The second involves modeling myeloid cell-directed immunosuppression in the tumor microenvironment, and how counterstrategies such as inhibiting STAT3 signaling, can enhance CAR-T cell trafficking and effector function.  The third project describes small tumor cell-derived extracellular vesicle (sEV) transport (convection and binding to the extracellular matrix) and how the sEV can establish spatial gradients to guide monocyte migration in the tumor microenvironment.  This talk will provide an overview of our major results from each of these projects.

Add to Calendar ▼2021-12-13 00:00:002021-12-15 00:00:00Europe/LondonOrganoids and Organs-on-Chips 2021Organoids and Organs-on-Chips 2021 in Coronado Island, CaliforniaCoronado Island,