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SELECTBIO Conferences Innovations in API Manufacture 2022

Volker Hessel's Biography

Volker Hessel, Professor, School of Chemical Engineering, The University of Adelaide

Professor Volker Hessel studied chemistry at Mainz University (PhD in organic chemistry, 1993). In 1994 he entered the Institut für Mikrotechnik Mainz GmbH. In 2002, Prof. Hessel was appointed Vice Director R&D at IMM and in 2007 as Director R&D. In 2005 and 2011, Prof. Hessel was appointed as Part-time and Full Professor at Eindhoven University of Technology, respectively. He was Honorary Professor at TU Darmstadt, Germany and is Guest Professor at Kunming University of Science and Technology, China. Prof. Hessel was appointed as Deputy Dean (Research) and Full Professor at the School of Chemical Engineering in the ECMS Faculty at the University of Adelaide, Australia. He is (co-)author of > 450 peer-reviewed (h-index: 54). He received the AIChE Award “Excellence in Process Development Research” in 2007, the ERC Advanced Grant “Novel Process Windows” in 2010, the ERC Proof of Concept Grant in 2017, the IUPAC ThalesNano Prize in Flow Chemistry in 2016, the FET OPEN Grant in 2016, and the ERC Synergy Grant 2018. He was authority in the 35-man teamed Parliament Enquete Commission "Future of the Chemical Industry" in Nordrhine-Westfalia.

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Life Cycle Assessment of Multistep Benzoxazole Synthesis: From Batch to Waste-Minimized Continuous Flow Systems

Thursday, 17 March 2022 at 17:45

Add to Calendar ▼2022-03-17 17:45:002022-03-17 18:45:00Europe/LondonLife Cycle Assessment of Multistep Benzoxazole Synthesis: From Batch to Waste-Minimized Continuous Flow SystemsInnovations in API Manufacture 2022 in

This presentation focuses on the progress of synthesis methods for the preparation of 2-aryl benzoxazoles as highly interesting materials with increasing relevance in the pharmaceutical industry (as well as in optical applications). The traditional production methods of 2-aryl benzoxazoles clearly have some drawbacks related to the use of strong acids and/or toxic reagents leading to a large production of waste. Importantly, a comprehensive analysis of the associated risk in terms of safety, environmental impact and disposal cost is lacking. In this regard, the life cycle assessment (LCA) methodology is herein applied to ultimately evaluate the environmental profile of the available routes to access 2-aryl benzoxazoles. Seven batch synthesis approaches and two continuous-flow (CF) approaches (small and large scale) are closely compared. The superiority of the CF technology is ultimately proven among the analysed environmental impact categories. The main finding is that the oxygen-flow chemistry intensification fortified the sustainability of the green chemistry principles (towards the catalyst/solvent) themselves by ensuring the regeneration of OMS catalysts and reduction of manganese leaching to the minimum by the CPME solvent, which also provided high solvent recyclability. In this way, it adds circularity in the sense of its 10R framework (e.g. R standing for recycle, repair, rethink, and refuse). As a result, for example, our flow approach reduces carbon emissions by 85% in comparison with our batch approach, the latter exhibiting lower environmental impact than the six batch approaches from the literature. In addition, our flow chemistry process has lower energy consumption and solvent load, whose share is up to 88% of the environmental impact.

Add to Calendar ▼2022-03-17 00:00:002022-03-18 00:00:00Europe/LondonInnovations in API Manufacture 2022Innovations in API Manufacture 2022 in