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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

Shinichiro Fuse's Biography



Shinichiro Fuse, Professor, Nagoya University

Shinichiro Fuse earned a BS in Chemical Engineering from Tokyo Institute of Technology in 2000, and a PhD in Applied Chemistry from Tokyo Institute of Technology under the supervision of Prof. Takashi Takahashi in 2005. He was a researcher at ChemGenesis Incorporated from 2005 to 2006, and a postdoctoral fellow with Prof. Daniel E. Kahne at Harvard University from 2006 to 2008. In 2008, he joined the faculty at the Tokyo Institute of Technology as an assistant professor. He moved to the Chemical Resources Laboratory at the same university as an associate professor in 2015. The affiliation name was changed to the Laboratory for Chemistry and Life Science in 2016. His research interests are micro-flow synthesis, natural product synthesis, and peptide synthesis. He received Asian Core Program/Advance Research Network Lectureship Award in 2017, Incentive Award in Synthetic Organic Chemistry, Japan in 2016, and Young Scientist's Research Award in Natural Product Chemistry in 2006. In 2019, he was promoted to Full Professor at Nagoya University.

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Micro-Flow Synthesis of Amino Acid N-Carboxy Anhydrides and Their Derivatization via pH Flash Switching and Rapid Dual Activation

Thursday, 10 September 2020 at 16:45

Add to Calendar ▼2020-09-10 16:45:002020-09-10 17:45:00Europe/LondonMicro-Flow Synthesis of Amino Acid N-Carboxy Anhydrides and Their Derivatization via pH Flash Switching and Rapid Dual ActivationMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Amino Acid N-Carboxy Anhydrides (NCAs) are important as monomers in polypeptide synthesis. The most conventional synthetic approach for NCAs uses strong acidic conditions. Therefore, NCAs containing acid-labile functional groups cannot be prepared. On the other hand, NCAs canbe rapidly generated under basic conditions, however, they rapidly occur overreactions under the basic conditions. We developed and used pH flash switching technology in a micro-flow reactor. Acid-labile NCAs were successfully prepared by our developed approach. We also demonstrated derivatization of labile NCAs using rapid dual activation of both NCAs and electrophiles in a micro-flow reactor.


Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com