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SELECTBIO Conferences Extracellular Vesicles 2022: Biology, Disease & Medicine

Xiaoli Yu's Biography

Xiaoli Yu, Assistant Professor, Department of Neurosurgery, University of Colorado Anschutz Medical Campus

Dr. Yu received her PhD in Cell and Molecular Biology from Colorado State University. Her postdoc training was in Neuroimmunology focusing on IgG antibodies and related antigens in patients with multiple sclerosis. Currently she is a research faculty in the Department of Neurosurgery at University of Colorado Anschutz Medical Campus. Her projects include the immunopathogenesis of Multiple Sclerosis, focusing on IgG antibodies as biomarkers and antibody-dependent cell-mediated cytotoxicity in demyelination. In addition, she and her collaborators are using phage-displayed random peptide library approaches to identify extracellular vesicles/exosomes as biomarkers for patients with brain tumors, traumatic brain injuries and other CNS disorders.

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Glioblastoma Extracellular Vesicle Specific Peptides Inhibit EV-induced Neuronal Cytotoxicity

Wednesday, 14 September 2022 at 14:00

Add to Calendar ▼2022-09-14 14:00:002022-09-14 15:00:00Europe/LondonGlioblastoma Extracellular Vesicle Specific Peptides Inhibit EV-induced Neuronal CytotoxicityExtracellular Vesicles 2022: Biology, Disease and Medicine in

Glioblastoma (GBM) is the most aggressive and lethal form of brain tumors. Tumor cells release extracellular vesicles (EVs) which have been shown to play a critical role in cellular communication in the tumor micro-environment. We discovered that GBM plasma EVs were smaller in size, had no relationship between size and concentration, but showed highly significant correlation between EV concentration and plasma protein concentration. Importantly, GBM EVs purified from both plasma and tumor cell line produced IgG-mediated, complement dependent cytotoxicity in neurons. We identified high affinity phage peptides for GBM EVs by screening phage-displayed random peptide libraries. Significantly, we showed that GBM EV peptides inhibit EV-induced complement-dependent cytotoxicity in neurons in dose- and time-dependent manner. Phage peptide technologies can be used for isolation and characterization of EVs derived from brain tumors. EV specific peptides can be explored for  biomarkers and mechanisms  of brain tumor EV-induced neuronal death.

Add to Calendar ▼2022-09-13 00:00:002022-09-14 00:00:00Europe/LondonExtracellular Vesicles 2022: Biology, Disease and MedicineExtracellular Vesicles 2022: Biology, Disease and Medicine in