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SELECTBIO Conferences Microfluidics & Flow Chemistry Europe 2020

Manuel Nuño's Biography

Manuel Nuño, Chief Scientific Officer, Vapourtec Ltd.

Dr. Manuel Nuño completed his MChem at Universidad de Zaragoza, Spain and York University, UK moving to University of Bath, UK to undertake his PhD in photocatalysis under the supervision of Dr Richard J. Ball.

Following completion of his PhD, Manuel advanced his process improvement skills during three years as process development chemist in food manufacturing industry working to improve the performance of large scale batch and flow chemical processes involving extraction, purification and crystallisation of sugars. Early in 2019 Manuel moved to Vapourtec ltd as a research scientist, offering applications and chemistry support to customer and product development teams. Projects he has worked with include, photochemistry in flow, flow peptide synthesis, organometallic chemistry in flow and continuous electrochemical oxidation of natural products.

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Applications of Continuous Flow Chemistry Systems for Organic Synthesis

Friday, 11 September 2020 at 09:00

Add to Calendar ▼2020-09-11 09:00:002020-09-11 10:00:00Europe/LondonApplications of Continuous Flow Chemistry Systems for Organic SynthesisMicrofluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The

Terpenes are low cost, natural products which can be modified into more added value products when a ketone or hydroperoxide group is introduced. Here we report a green approach to perform such C-H functionalisations. Vapourtec has recently developed the Ion Electrochemical Reactor, which takes advantage of the extremely large surface-to-volume ratios that a flow microreactor provides to make selective electrochemical oxidation of terpenes. The applications of electrochemistry in flow will be discussed, showing also the examples of working with a divided cell design. Singlet oxygen is a powerful reagent in organic synthesis, and its generation in a continuous flow photochemical reactor is safer than in traditional batch routes. With the use of the newly developed 420 nm UV High Power LED, we report a high throughput ene like reactions of singlet oxygen with citronellol. The final part of the talk will focus on solid-phase peptide synthesis in flow. Although SPPS is a well-established technique, the lack of live inline data can lead to several problems, such as an incomplete peptide and waste of reagents. By recording the volume change in a variable bed flow reactor and, combined with an inline UV detector, Vapourtec’s team was able to evaluate difficult couplings and develop optimised conditions.

Add to Calendar ▼2020-09-10 00:00:002020-09-11 00:00:00Europe/LondonMicrofluidics and Flow Chemistry Europe 2020Microfluidics and Flow Chemistry Europe 2020 in Rotterdam, The NetherlandsRotterdam, The