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SELECTBIO Conferences 3D-Models for Drug Testing: Organoids & Tissue Chips 2022

John Rogers's Biography

John Rogers, Simpson/Querrey Professor of Materials Science and Engineering, Northwestern University

John A. Rogers is the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Medicine at Northwestern University, with affiliate appointments in Mechanical Engineering, Electrical and Computer Engineering and Chemistry, where he is also Director of the recently endowed Querrey Simpson Institute for Bioelectronics. He has published more than 800 papers, is a co-inventor on more than 100 patents and he has co-founded several successful technology companies. His research has been recognized by many awards, including a MacArthur Fellowship (2009), the Lemelson-MIT Prize (2011), the National Security Science and Engineering Faculty Fellowship (2012), the Smithsonian Award for American Ingenuity in the Physical Sciences (2013), the MRS Medal (2018), the Benjamin Franklin Medal from the Franklin Institute (2019), the Sigma Xi Monie Ferst Award (2021) and a Guggenheim Fellowship (2021). He is a member of the National Academy of Engineering, the National Academy of Sciences, the National Academy of Medicine, the National Academy of Inventors and the American Academy of Arts and Sciences.

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3D Mesoscale Structures as Bioelectronic Interfaces to Cortical Spheroids

Wednesday, 14 September 2022 at 10:00

Add to Calendar ▼2022-09-14 10:00:002022-09-14 11:00:00Europe/London3D Mesoscale Structures as Bioelectronic Interfaces to Cortical Spheroids3D-Models for Drug Testing: Organoids and Tissue Chips 2022 in

Three-dimensional (3D), sub-millimeter-scale collections of neural cells, known as cortical spheroids and organoids, are of rapidly growing importance in neuroscience research due to their ability to reproduce complex features of brain architecture, function and organization in vitro. Despite their great potential for studies of neurodevelopment, neurological disease modeling and evolution, these miniaturized, fragile 3D living biosystems cannot be examined easily using conventional methods for neuromodulation, sensing and manipulation.   This talk describes an unusual 3D neurotechnology platform that can be tailored with shapes, sizes and complex geometries that match those of individual organoids/spheroids and small collections of them, sometimes referred to as assembloids. Systematic studies demonstrate various electrical, thermal, chemical and optical modes of operation that can be supported by these frameworks, including examples of their use in monitoring electrophysiological behaviors across the surfaces of healthy human stem cell derived cortical spheroids and in examining processes of neuroregeneration between lobes of transected assembloids formed from pairs of spheroids.

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