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SELECTBIO Conferences The Space Summit 2021

Livia Visai's Biography

Livia Visai, Associate Professor, University of Pavia

Associate Professor in Biochemistry, Department of Molecular Medicine (DMM), Faculty of Medicine, University of Pavia, Pavia, Italy; Referent of the Academic Strategic project of University of Pavia titled “Center for Health Technologies” (CHT), Coordinator of the Nanomedicine Pillar, Pavia, Italy; Operating as Associate Professor within the National Health Service of the Scientific Clinical Institutes (ICS) Maugeri, Società Benefit Spa, IRCCS, Pavia, Italy; ISTEC-CNR Associate position, Faenza, Italy; Type A Researcher at INSTM, Firenze, Italy.

Field of Research Interests:

Nanomedicine in tissue regeneration, in cancer treatment, and in bacterial infection reduction.

Assessment of nanoparticles effect on bone remodeling using the Random Positioning Machine (RPM) and the International Space Station (ISS)

Study of adhesion, proliferation and differentiation of stem cells or other type of cells on nano- and micro-structured scaffolds

Development and biological characterization of nanosystems for delivery of anticancer drugs

Characterization of biomaterials/scaffolds containing metal nanoparticles with antibacterial function; selection and characterization of human single chain Fragment variable (scFv) against bacterial adhesins

List of publications is listed at :

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The NATO Project: Nanoparticle-based Countermeasures for Microgravity-induced Osteoporosis

Thursday, 30 September 2021 at 15:00

Add to Calendar ▼2021-09-30 15:00:002021-09-30 16:00:00Europe/LondonThe NATO Project: Nanoparticle-based Countermeasures for Microgravity-induced OsteoporosisThe Space Summit 2021 in

Recent advances in nanotechnology applied to medicine and regenerative medicine have an enormous and unexploited potential for future space and terrestrial medical applications. The Nanoparticles and Osteoporosis (NATO) project aimed to develop innovative countermeasures for secondary osteoporosis affecting astronauts after prolonged periods in space microgravity. Calcium- and Strontium-containing hydroxyapatite nanoparticles (nCa-HAP and nSr-HAP, respectively) were previously developed and chemically characterized. This study constitutes the first investigation of the effect of the exogenous addition of nCa-HAP and nSr-HAP on bone remodeling in gravity (1 g), Random Positioning Machine (RPM) and onboard International Space Station (ISS) using human bone marrow mesenchymal stem cells (hBMMSCs). In 1 g conditions, nSr-HAP accelerated and improved the commitment of cells to differentiate towards osteoblasts, as shown by the augmented alkaline phosphatase (ALP) activity and the up-regulation of the expression of bone marker genes, supporting the increased extracellular bone matrix deposition and mineralization. The nSr-HAP treatment exerted a protective effect on the microgravity-induced reduction of ALP activity in RPM samples, and a promoting effect on the deposition of hydroxyapatite crystals in either ISS or 1 g samples. The results indicate the exogenous addition of nSr-HAP could be potentially used to deliver Sr to bone tissue and promote its regeneration, as component of bone substitute synthetic materials and additive for pharmaceutical preparation or food supplementary for systemic distribution.

Add to Calendar ▼2021-09-30 00:00:002021-10-01 00:00:00Europe/LondonThe Space Summit 2021The Space Summit 2021 in