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SELECTBIO Conferences The Space Summit 2021

Begum Alaybeyoglu's Biography

Begum Alaybeyoglu, Principal Scientist, Javelin Biotech

Begum is the systems biology team lead at Javelin Biotech. Her team focuses on bioinformatics analysis of multi-omics data and systems biology approaches for preclinical target discovery. Before her current role, she was a postdoctoral associate at the Department of Biological Engineering, Massachusetts Institute of Technology, where she worked on multiscale modeling and quantitative assessment of microphysiological system (MPS) technologies for translational research. Begum got her Ph.D. in Chemical Engineering from Bogazici University, where she worked in the multidisciplinary Biosystems Engineering Research Group.

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A Systems Biology Approach to Post-Traumatic Osteoarthritis (PTOA) Disease Biology and Biomarkers

Friday, 1 October 2021 at 15:30

Add to Calendar ▼2021-10-01 15:30:002021-10-01 16:30:00Europe/LondonA Systems Biology Approach to Post-Traumatic Osteoarthritis (PTOA) Disease Biology and BiomarkersThe Space Summit 2021 in

Understanding metabolic dysregulation in musculoskeletal disorders facilitates discovery of biomarkers and supports development of disease modifying drugs (DMDs). Previous omics studies provided extensive knowledge and diagnostic marker candidates for osteoarthritis (OA), despite the lack of consensus in molecular signature due to disease heterogeneity and patient variability. Our study focused on circulating metabolites for investigation of non-invasive early biomarkers of post-traumatic OA (PTOA) to understand disease initiation and progression using an ex vivo human disease model. We studied the altered metabolism on earth and in space to demonstrate donor variability and effect of microgravity for discovery of early PTOA disease biomarkers and DMDs.

Add to Calendar ▼2021-09-30 00:00:002021-10-01 00:00:00Europe/LondonThe Space Summit 2021The Space Summit 2021 in