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SELECTBIO Conferences Clinical Translation of Organoids and Organs-on-Chips 2022

Mario Rothbauer's Biography



Mario Rothbauer, Principle Investigator, Medical University of Vienna

Mario Rothbauer received an MSc. in Biomedical & Tissue Engineering at the University of Applied Sciences Technikum Wien (Vienna, Austria) in 2001 and completed his doctorate in food science and biotechnology in 2015 at the University of Natural Resources and Life Sciences (BOKU; Vienna, Austria). At the AIT Austrian Institute of Technology (Vienna, Austria) he worked on the development of lab-on-a-chip systems for cell-based applications that combine cell biology, nanobiotechnology, biosensors and materials science with state-of-the-art microfabrication technologies. As Post-Doc at the CellChipGroup of the Vienna University of Technology (Vienna, Austria) he worked on human barrier-, organ- and multi-organ-on-a-chip as well as human disease models for toxicological and pharmaceutical research with the overall aim to create valid alternatives to animal tests. Since 2019, as PI he develops microphysiological systems for musculoskeletal diseases at the Karl Chiari Lab for Orthopaedic Biology at the Department of Orthopedics and Trauma Surgery of the Medical University of Vienna (Vienna, Austria) with a thematic focus on rheumatoid arthritis and osteoarthritis.

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Bioengineering the Inflammatory and Degradative Cross Talk in Arthritic Diseases with Patient-derived Chondro-synovial Joint-on-a-chip Systems

Tuesday, 22 March 2022 at 14:30

Add to Calendar ▼2022-03-22 14:30:002022-03-22 15:30:00Europe/LondonBioengineering the Inflammatory and Degradative Cross Talk in Arthritic Diseases with Patient-derived Chondro-synovial Joint-on-a-chip SystemsClinical Translation of Organoids and Organs-on-Chips 2022 in BostonBostonSELECTBIOenquiries@selectbiosciences.com

Arthritic musculoskeletal diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA) concern great parts of our global population. The communication of multiple tissues during onset and progression is characterized by inflammatory as well as degradative molecular processes that can in strong pathologies lead to join replacement surgery. The inflammatory and degradative interaction of joint tissues plays a vital role to aggravate tissue degradation in both arthritic diseases. The first half of the talk will cover the development of a chondro-synovial joint-on-a-chip system using patient-derived organoids and discuss how to develop an animal- and animal-product-free system with regards to serum supplements and biomatrices. The second half will outline the advances and progress made in modelling an authentic patient tissue-like osteoarthritis phenotype at architectural and molecular level using chondro-synovial joint-on-a-chip systems.


Add to Calendar ▼2022-03-21 00:00:002022-03-22 00:00:00Europe/LondonClinical Translation of Organoids and Organs-on-Chips 2022Clinical Translation of Organoids and Organs-on-Chips 2022 in BostonBostonSELECTBIOenquiries@selectbiosciences.com