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SELECTBIO Conferences Innovations in API Manufacture 2022

Gianvito Vilé's Biography

Gianvito Vilé, Associate Professor in Chemical Engineering, Politecnico di Milano

Prof. Dr. Gianvito Vilé graduated with honors in Chemical Engineering from Politecnico di Milano and received his PhD from ETH Zurich. He is currently an associate professor at Politecnico di Milano. His research focuses on the understanding of the structure and reactivity of single-atom catalysts, and on the design of continuous-flow catalytic methods. He has received numerous awards for his research, including the ETH Zurich Medal for outstanding doctoral thesis, the Dimistris N. Chorafas Award from the Weizmann Institute of Sciences in Israel, and the Felder Award from the Bracco pharmaceutical company. He was also selected among the most influential researchers by leading journals of the American Chemical Society, Royal Society of Chemistry, and Institute of Physics. Twitter: @VileGroup, website:

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Continuous-Flow C-C Coupling via Single-Atom Catalysis

Thursday, 17 March 2022 at 09:45

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Flow synthesis and single-atom catalysis are currently attracting a wide attention for sustainable chemical and pharmaceutical synthesis. In this lecture, I will demonstrate the synergistic merger of metallic single-atom catalysis and flow chemistry for the cross-coupling synthesis of pharmaceutically-relevant intermediates. Specifically, the metal and redox catalytic cycles are combined within one single-atom material which can be easily recovered and re-used in a flow reactor for several times, preserving its activity between individual trials. Finally, with the help of DFT calculations, I will elucidate the active site of the single-atom material and propose a plausible reaction mechanism for the flow reaction.

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