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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics Europe 2022

Sara Abalde-Cela's Biography

Sara Abalde-Cela, Staff Researcher, International Iberian Nanotechnology Laboratory

Dr Sara Abalde-Cela is a Staff Researcher and the Health Cluster Coordinator at the International Iberian Nanotechnology Laboratory (INL), Braga, Portugal. Her experience in research ranges from nanotechnology, nanosensors and Raman spectroscopy to microfluidics and microdroplets. Her research focuses on the development of optofluidic platforms for the diagnosis and monitoring of diseases, as part of the Medical Devices group. Mainly, she applies SERS spectroscopy as an interrogation technique to develop novel biosensors, mostly directed to the detection and monitoring of the behaviour of single cancer cells and underlying mechanisms behind cancer and metastasis. Sara holds a PhD in nanotechnology by the Universidade de Vigo (Spain) and postdoctoral experience at the University of Cambridge. Sara is also the co-founder and CTO of the start-up RUBYnanomed (2018 – now) dedicated to technology transfer of microfluidic-based medical devices for liquid biopsy.

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Optofluidic Devices For Disease Diagnosis

Tuesday, 21 June 2022 at 15:00

Add to Calendar ▼2022-06-21 15:00:002022-06-21 16:00:00Europe/LondonOptofluidic Devices For Disease DiagnosisLab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The

The capacity of microfluidic platforms as tiny labs transitioned from a potential to a reality as demonstrated in the past 20 years. The microfluidics community developed extremely advanced systems able to perform almost any chemical and/or biological lab protocol. However, in order to develop integrated lab-on-a-chip diagnostic platforms, it is crucial to couple microfluidic devices with detection strategies able to match the inherent properties of microfluidics: high-throughput, automation and miniaturization. One of those detection techniques is surface-enhanced Raman scattering (SERS) spectroscopy, an ultrasensitive and highly selective analytical technique with multiplexing ability. SERS is based on the use of plasmonic nanoparticles that act as nanoantennas and augment the very specific Raman signatures of molecules close to the nanostructured surfaces. We will show how the integration of different SERS sensing substrates and strategies within microfluidics and microdroplets offers a great flexibility for the diagnosis of several biological species and/or events. We will show examples in the context of liquid biopsy demonstrating the single-cell multiplex phenotypic analysis in a microdroplet, the detection of panels of mutations in cancer or the differentiation of cancer versus healthy cells. These approaches may be transferred to different analytical fields, such as the detection and discrimination of foodborne pathogens, bacteria or viruses in food or water samples.

Add to Calendar ▼2022-06-21 00:00:002022-06-22 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics Europe 2022Lab-on-a-Chip and Microfluidics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The