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SELECTBIO Conferences Extracellular Vesicles & Nanoparticle Therapeutics Europe 2022

Mattis Holma's Biography



Mattis Holma, R&D Scientist, Amniotics

Mattis Holma Image

Extracellular Vesicles from Skin Selected Amniotic Fluid MSCs Improve Wound Healing in vitro

Monday, 24 October 2022 at 16:00

Add to Calendar ▼2022-10-24 16:00:002022-10-24 17:00:00Europe/LondonExtracellular Vesicles from Skin Selected Amniotic Fluid MSCs Improve Wound Healing in vitroExtracellular Vesicles and Nanoparticle Therapeutics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com

Neonatal mesenchymal stem cells (MSC) derived from term amniotic fluid (TAF) were sorted with a skin specific marker identified with RNASeq data from TAF-MSC clones. One of these markers was used for cell-sorting using Tyto MACSQuant cell sorter and the positive cell population was expanded to final product stage (CutiStem). CutiStem cells were starved and secretome was collected. Extracellular vesicles were purified by ultracentrifugation and characterized. A THP-1 assay showed that EV derived from CutiStem reduce inflammation by downregulation of the NK- ?B. Furthermore, a scratch assay with human dermal fibroblasts revealed that EV derived from Cutistem also increase wound healing in vitro.


Add to Calendar ▼2022-10-24 00:00:002022-10-25 00:00:00Europe/LondonExtracellular Vesicles and Nanoparticle Therapeutics Europe 2022Extracellular Vesicles and Nanoparticle Therapeutics Europe 2022 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com