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SELECTBIO Conferences The Space Summit Europe 2023

Daniel Carvalho's Biography

Daniel Carvalho, Research Fellow, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University

Daniel Carvalho is a PhD student at the Institute for Technology-Inspired Regenerative Medicine (MERLN), The Netherlands, where he develops new organ-on-a-chip platforms for the Horizon 2020 SCREENED project. Daniel obtained his Integrated Masters in Bioengineering at the University of Porto (Portugal) in 2016. Since then, he was interested in understanding the effects of near-weightlessness in biological systems and has participated in multiple educational programs of the European Space Agency (ESA). After completing his Masters degree, Daniel worked as a research assistant in the field of gravitational cell biology at Otto von Guericke Magdeburg University (Germany) and Aarhus University (Denmark), where he joined the scientific team of the CellBox-2 spaceflight mission (SpaceX CRS13).

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Lock-and-Play Bioreactor Platforms for Advanced Microphysiological Systems

Tuesday, 28 March 2023 at 12:00

Add to Calendar ▼2023-03-28 12:00:002023-03-28 13:00:00Europe/LondonLock-and-Play Bioreactor Platforms for Advanced Microphysiological SystemsThe Space Summit Europe 2023 in Rotterdam, The NetherlandsRotterdam, The

Over the past two decades, organ-on-a-chip (OoC) devices have enabled major breakthroughs as surrogates of human tissues for a wide range of biomedical applications, from precise medicine to predicative drug screening platforms. In recent years, the incorporation of complex, 3D tissue-specific organoids into OoC devices has been shown to be synergetic and desired to create more physiologically relevant 3D in vitro models. However, the addition of such organoids has increased the complexity of already existing complex microfluidic systems.  New and more versatile designs are urgently needed to facilitate chip operability, increase throughput and the success rate of complex, 3D cell cultures. Our lab has developed a new line of bioreactor platforms to facilitate the culture and screening of embryonic stem cell-derived thyroid follicles. The developed platforms integrate a reversible fastening concept entitled Lock-and-Play, which allows devices to be quickly opened and closed before, after and during operation, such that organoids can be directly accessed whenever needed. This presentation will provide an overview about these devices and future directions towards the development of next-generation OoC platforms that can find applications across the biomedical field, including for near-weightlessness and spaceflight studies. In doing so, initial studies on how the developed OoC platform can be easily modified to further include more advanced in vitro 3D models such as biofabricated ones, so that their adoption in the Biofabrication and 3D cell culture facilities that are being developed at ISS can be facilitated.

Add to Calendar ▼2023-03-27 00:00:002023-03-28 00:00:00Europe/LondonThe Space Summit Europe 2023The Space Summit Europe 2023 in Rotterdam, The NetherlandsRotterdam, The