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SELECTBIO Conferences Microphysiological Systems 2023: A Deep Dive into Technologies & Applications

Martin Trapecar's Biography

Martin Trapecar, Assistant Professor, Johns Hopkins University

Martin Trapecar is an assistant professor of medicine and biomedical engineering at JHU and serves as the associate director of the JHU Center for Microphysiological Systems. He founded the Laboratory of Human Biomimetics at the JHU All Children's Hospital in St. Petersburg Florida, which is developing novel models of complex human biology. His lab is focused on better understanding inter-organ communication in the context of immunity and metabolism. He recently received the R35 MIRA award for new investigators and serves as co-Investigator in the recently NASA-funded mechanism to extend the longevity of MPS models.

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Multiorgan Microphysiological Systems as Tools to Study Complex Diseases

Wednesday, 26 July 2023 at 14:30

Add to Calendar ▼2023-07-26 14:30:002023-07-26 15:30:00Europe/LondonMultiorgan Microphysiological Systems as Tools to Study Complex DiseasesMicrophysiological Systems 2023: A Deep Dive into Technologies and Applications in Orlando, FloridaOrlando,

Human multiorgan microphysiological systems (MOMPS) are engineered environments whose purpose is to mimic native cellular surroundings. This is accomplished with the use of tissue-specific biomaterials, machined or printed 3D architecture and perfusion. Controlled interaction of individual human tissues and the scalability of biological complexity in MOMPS, supported by advances in systems biology, might hold the key to identify novel relationships between interorgan crosstalk, metabolism, and immunity. The Trapecar lab is integrating donor-matched tissues into MOMPS to investigate how i) interorgan communication directs complex tissue development and organ-level renewal and how ii) a disruption thereof leads to emergence of immunometabolic pathologies. We show that tissue-level interaction between and within the three main germ layers ectoderm (neurons), mesoderm (lymphoid) and endoderm (gut and liver) leads to increased tissue maturation and increased in vivo-like functionality. In our approach we reconstruct donor-matched hepatic, gut-mucosal and neuronal tissue under fluidic communication and presence of the donors circulating immune cells. We further use the established system to derive how a metabolic disruption in immune-tissue signaling contributes to overlapping inflammatory disorders of the gut-liver-brain axis such as inflammatory bowel disease and neurodegeneration. Paired with multiomic analysis and resolution into molecular underpinnings of cellular and tissue homeostasis, MOMPS represent a unique opportunity to systematically dissect how interactions at a lower order inform new behavior at the macroscale within and between organ systems. Such scalable complexity might yield new insight into fundamental emergence of disease and tissue regeneration.

Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonMicrophysiological Systems 2023: A Deep Dive into Technologies and ApplicationsMicrophysiological Systems 2023: A Deep Dive into Technologies and Applications in Orlando, FloridaOrlando,