Eduardo Reategui,
Distinguished Assistant Professor of Engineering ,
The Ohio State University
Dr. Eduardo Reátegui is a Distinguished Assistant Professor of Engineering Inclusive Excellence in the Department of Chemical and Biomolecular Engineering at The Ohio State University. He is also a member of the Molecular Biology and Cancer Genetics Program at the James Comprehensive Cancer Center. He obtained his Ph.D. at the University of Minnesota in 2012. After graduation, he was a postdoctoral research fellow at Harvard Medical School and the Massachusetts General Hospital Cancer Center in Boston. Dr. Reátegui’s research integrates microtechnologies, biomaterials, and molecular imaging strategies for high-throughput sorting and molecular profiling of circulating disease biomarkers and developing infection/inflammation on-a-chip devices for the biophysical and molecular characterization of immune cell interactions with pathogens and cancer cells.
Characterization of Proteins and Extracellular RNAs in Vesicles and Viruses for Cancer and COVID-19 Detection
Wednesday, 26 July 2023 at 11:15
Add to Calendar ▼2023-07-26 11:15:002023-07-26 12:15:00Europe/LondonCharacterization of Proteins and Extracellular RNAs in Vesicles and Viruses for Cancer and COVID-19 DetectionExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
Liquid biopsies consist of sampling and analysis of tumor-derived content from a blood draw, and they are rapidly gaining interest in the laboratory and clinic due to significant advantages over traditional tissue analysis (e.g., frequent sampling, less invasive). One “candidate” to develop liquid biopsy assays are extracellular vesicles (EVs). EVs are shed continuously from tumor cells as tiny lipid nanoparticles and have been identified in different biofluids. EVs can be used as a surrogate for tumor cells since they carry similar proteins, mRNAs, miRNAs, and DNAs. This presentation will describe an ultrasensitive detection method for in-situ simultaneous protein and RNA profiling of EV subpopulations at the single vesicle level by total internal reflection fluorescence (TIRF) microscopy. We recently leveraged our expertise into single virus particle characterization that outperforms standard antigen and molecular detection methods for SARS-CoV-2. Our different technologies' translational potential will be shown through proof of concept experiments performed with clinical samples from cancer and COVID-19 patients.
Add to Calendar ▼2023-07-26 00:00:002023-07-27 00:00:00Europe/LondonExtracellular Vesicles 2023: Technologies, Biomarker Cargo and DiagnosticsExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2023-07-26 11:15:002023-07-26 12:15:00Europe/LondonCharacterization of Proteins and Extracellular RNAs in Vesicles and Viruses for Cancer and COVID-19 DetectionExtracellular Vesicles 2023: Technologies, Biomarker Cargo and Diagnostics in Orlando, FloridaOrlando, FloridaSELECTBIOenquiries@selectbiosciences.com
