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SELECTBIO Conferences Flow Chemistry European Summit 2024

Nina Hartrampf's Biography

Nina Hartrampf, Assistant Professor, University of Zurich

Nina Hartrampf studied chemistry and biochemistry at Ludwig-Maximilians-Universität Munich (Germany) and obtained her PhD in the field of natural product synthesis and chemical biology in the group of Dirk Trauner. She then moved to the group of Brad Pentelute at the Massachusetts Institute of Technology (USA) as a postdoctoral researcher, where she worked on the optimization of flow-based peptide synthesis using an automated synthesis platform.

In 2020, she moved to the University of Zurich (Switzerland) as an assistant professor (tenure track). Her research group focuses on the development of new tools for flow-based peptide synthesis as well as the chemical synthesis of post-translationally modified peptides and proteins. Her work has been recognized with the 2019 Bert Schram Award from the American Peptide Society, the 2021 Bachem Award for Peptide Science, and the 2022 Thieme Journals Award.

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Flow-based Methods for Chemical Peptide and Protein Synthesis

Monday, 25 March 2024 at 14:30

Add to Calendar ▼2024-03-25 14:30:002024-03-25 15:30:00Europe/LondonFlow-based Methods for Chemical Peptide and Protein SynthesisFlow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The

The field of biopharmaceuticals is rapidly expanding, requiring new methods for the on-demand production of chemically modified peptides and proteins. This chemical synthesis involves the iterative formation of amide bonds and requires high yields for efficient incorporation of each individual amino acid. Solid-phase peptide synthesis (SPPS) has been a standard method for chemical peptide and protein production for the past 60 years, but its outcome can be highly dependent on the peptide sequence synthesized. One issue that often arises is the aggregation of growing peptide chains on the solid support, which can lead to incomplete couplings ("difficult sequences”), and this effect generally correlates with low synthesis yields. Previous research into this sequence-dependent phenomenon was limited by the lack of high-throughput analytical methods, thus impeding systematic analysis.

As opposed to batch-SPPS, flow-SPPS not only accomplishes rapid synthesis of tailored peptides and proteins but also enables the collection of in-line analytical data that gives new insights into sequence-dependent events such as aggregation. In this presentation, various parameters affecting aggregation will be analyzed, and the development of new computational methods, technological solutions, and synthetic tools to reduce the sequence dependence in SPPS will be disclosed.

Add to Calendar ▼2024-03-25 00:00:002024-03-26 00:00:00Europe/LondonFlow Chemistry European Summit 2024Flow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The