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SELECTBIO Conferences Flow Chemistry European Summit 2024

Rajat Pandey's Biography

Rajat Pandey, Postdoctoral Fellow, Nelson Mandela University

Rajat Pandey conducted his PhD with Prof. R. Vijaya Anand at the Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Punjab, India. His thesis was entitled "Metal-free approaches for the synthesis of N-heterocycles and diarylmethanes under batch as well as continuous-flow conditions." Since 2023 he has been working as a postdoctoral research fellow at Nelson Mandela University with Prof Paul Watts on the synthesis of APIs in flow reactors.

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Flow Enabled Synthesis of Multiresistant Drug Clofazimine

Tuesday, 26 March 2024 at 18:00

Add to Calendar ▼2024-03-26 18:00:002024-03-26 19:00:00Europe/LondonFlow Enabled Synthesis of Multiresistant Drug ClofazimineFlow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The

Drug resistance to tuberculosis is still one of the significant challenges worldwide. Clofazimine, which belongs to the riminophenazine (anti-biotic) class, is still one of the active drugs that are efficient against drug resistance M. Tuberculosis. Apart from this, it is also a WHO-approved drug for the treatment of leprosy (Hansen's Disease) and, at present, is under phase 2 clinical trial for its activity against the SARS-CoV-2 virus. Owing to its vast importance in clinical research, we have developed a continuous-flow mediated synthesis of clofazimine using readily available p-chloroaniline and 1-fluro-2-nitrobenzene. The target drug molecule was obtained from four consecutive chemical transformations with nominal reaction time and improved purity and yields when compared to the batch process. Moreover, the first two steps were also successfully telescoped under optimized reaction conditions.

Add to Calendar ▼2024-03-25 00:00:002024-03-26 00:00:00Europe/LondonFlow Chemistry European Summit 2024Flow Chemistry European Summit 2024 in Rotterdam, The NetherlandsRotterdam, The