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SELECTBIO Conferences Point-of-Care, Biosensors and Rapid Dx Europe 2024

Maud Linssen's Biography

Maud Linssen, Researcher, Eindhoven University of Technology (TU/E)

Maud obtained her Masters degree in Analytical Chemistry at the University of Amsterdam and the Vrije Universiteit. After her master, she started her PhD at the molecular biosensing group at Eindhoven University of Technology under supervision of Prof. Dr. Ir. Menno Prins. Within her PhD, Maud is developing a sensor for continuous cytokine sampling and measuring using Biosensing by Particle Motion.

Maud Linssen Image

Towards Continuous Cytokine Monitoring in Organ-based Platforms

Tuesday, 25 June 2024 at 16:30

Add to Calendar ▼2024-06-25 16:30:002024-06-25 17:30:00Europe/LondonTowards Continuous Cytokine Monitoring in Organ-based PlatformsPoint-of-Care, Biosensors and Rapid Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The

Investigations on organ-based platforms such as organoids, organ-on-a-chip, and transplantation organs, require monitoring strategies in order to optimally control the biological systems. However, there is a lack of tools to continuously measure specific low-concentration biomarkers with minimal perturbation. Biosensing by Particle Motion (BPM) is a sensing method with single-molecule resolution that has been specifically designed to enable the continuous monitoring of biomolecules at low concentrations, such as nucleic acids, metabolites, proteins and hormones. The method relies on tracking the motion of individual biofunctionalized particles (1 µm in diameter) that interact with a biofunctionalized substrate. The particles switch between bound and unbound states due to reversible single-molecule interactions, dependent on the presence of analyte molecules. Recently, sampling by microdialysis has been investigated [3]. In this paper we present the development of a BPM sensor to measure cytokines, exemplified with the detection of Interleukin-6 and TNF-a. We will present a study of molecular binders and coupling strategies, focusing on sensitivity and reversibility of the sensor. Furthermore, measurements with microdialysis will be shown. Finally, we will discuss the prospects of using BPM and microdialysis for the continuous monitoring of low-concentration biomarkers in organ-based platforms.

Add to Calendar ▼2024-06-24 00:00:002024-06-25 00:00:00Europe/LondonPoint-of-Care, Biosensors and Rapid Dx Europe 2024Point-of-Care, Biosensors and Rapid Dx Europe 2024 in Rotterdam, The NetherlandsRotterdam, The