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SELECTBIO Conferences BioMEMS, Microfluidics & Biofabrication: Technologies and Applications

Hsueh-Chia Chang's Biography

Hsueh-Chia Chang, Bayer Professor of Engineering; Director, Center for Microfluidics and Medical Diagnostics, University of Notre Dame

Chia Chang received his BS and PhD degrees in Chemical Engineering from Caltech and Princeton. His group's research in electrokinetics and microfluidics has produced several on-chip micro-pumping, mixing, cell manipulation, electrical and plasmonic molecular sensing technologies. Some of them are being commercialized by three start-ups. One company that works closely with the Notre Dame Haiti program, FCubed LLC,, now employs 17 employees and has attracted more than $10 million in investment. Over 20 of Chia's group alumni now hold faculty positions over all six continents. He is the founding and chief editor of Biomicrofluidics, an American Institute of Physics journal.

Hsueh-Chia Chang Image

A Solid-State Nanopore microRNA Quantification Platform

Thursday, 16 March 2017 at 11:30

Add to Calendar ▼2017-03-16 11:30:002017-03-16 12:30:00Europe/LondonA Solid-State Nanopore microRNA Quantification

We report a new highly selective (PCR-free) solid-state nanopore miRNA quantification platform for liquid biopsy and single-cell assays. A single ion-track nanopore in a PET membrane is asymmetrically etched into a conic geometry and is coated with a high-permittivity dielectric layer by Atomic Layer Deposition.  The surface modified conic nanopore allows for high throughput molecular translocation (100 Hz vs 1 Hz for protein nanopores) and selective delay of single-stranded (ss) nucleic acids compared to their hybridized double-stranded (ds) duplex (mean translocation time of 100 ms vs 1 ms with 5% overlap in the two distributions). The delay is due to enhanced van der Waal attraction between exposed rings of the ss-nucleic acids, with delocalized electrons, with the high-permittivity coating. Individual translocation events can be recorded for a mixture of ss- and ds-nucleic acids numbering between 100 to 100,000.  Whether the translocating molecule of each event is an ss miRNA or its ds duplex can be discerned with 95% confidence.

Add to Calendar ▼2017-03-16 00:00:002017-03-17 00:00:00Europe/LondonBioMEMS, Microfluidics and Biofabrication: Technologies and