Shopping Cart (0)
My Account

Shopping Cart
SELECTBIO Conferences Lab-on-a-Chip, Microfluidics & Microarrays World Congress 2016

Hsueh-Chia Chang's Biography



Hsueh-Chia Chang, Bayer Professor of Engineering, University of Notre Dame

H-C (Chia) Chang is a leader in electrokinetics, an important micro/nanofluidic technology for biochip platforms in future disease diagnostic products. His approach combines insightful theoretical analysis with simple but creative experiments to uncover new electrokinetic phenomena or to verify speculated ones. These new phenomena then led to inventions in new molecular diagnostics that use non-equilibrium electrokinetics and field-focusing physics to dramatically improve the performance of equilibrium probe-based assays without external fields. He and his PhD and postdoc students are inventors of 10 Notre Dame patents and 6 provisional patents, the largest IP output from any lab at Notre Dame. Five technologies have been licensed by startups near Notre Dame. One startup FCubed LLC will be going public this year. Another startup AgenDx has just licensed another of his technologies. Since 2000, 18 PhD and post-doc students of the Chang laboratory have embarked on academic careers as tenure-track professors at Chemical Engineering, Mechanical Engineering, Electrical Engineering, Food Science, Chemistry departments in 5 continents. Chia is the coauthor of a seminal book on Electrokinetics and he is the Founding Editor of Biomicrofluidics, the first American Institute of Physics journal in biology. He has published over 270 articles with 13,000 citations and an H-index of 63.

Hsueh-Chia Chang Image

A Billion-Droplet AC Electrospray Digital PCR Platform for Large-Dynamic Range Nucleic Acid Quantification

Tuesday, 27 September 2016 at 10:00

Add to Calendar ▼2016-09-27 10:00:002016-09-27 11:00:00Europe/LondonA Billion-Droplet AC Electrospray Digital PCR Platform for Large-Dynamic Range Nucleic Acid QuantificationLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

An AC-electrospray technology is shown to be able to generate 1 billion femto-liter (micron diameter) aqueous drops in immiscible silicone oil in less than 20 minutes.  Unlike DC sprays, which tend to suffer from dielectric breakdown in liquid, and droplet generation technologies based on hydrodynamic shear, which can only generate pico-liter drops, we have shown that a properly tuned AC field can entrain low-mobility anions at a meniscus and the Coulombic repulsion among such entrained ions can deform the meniscus into unique 11 degree AC cones that are quite distinct from and much stable than DC cones (Phys Rev Lett, 101, 204501(2008); 109, 224301(2012); LabChip, 15, 1656(2015)).   The sharper AC cones can generate 1 million femto-liter drops per second.  The larger drop number and concentration (nM) allow us to get significantly better accuracy (without using Poisson statistics), dynamic range (8 decades) and reduction of inhibition and interfering effects in heterogeneous media.  We have fabricated an integrated AC electrospray chip with PCR and imaging modules and have favorably compared the performance of this new droplet digital PCR platform against qPCR. The new AC droplet digital PCR platform is, however, a low-cost turn-key technology that requires no or minimum sample pretreatment.


Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016Lab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com