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SELECTBIO Conferences Liquid Biopsies and Minimally-Invasive Diagnostics 2016

Louise Laurent's Biography

Louise Laurent, Associate Professor, University of California-San Diego

Louise Laurent is Associate Professor in Reproductive Medicine at the University of California, San Diego. She received her residency training in Obstetrics and Gynecology and her clinical fellowship training in Maternal Fetal Medicine at UC San Diego. Her graduate research at UCSF included a large scale mutagenesis and molecular tracking strategy to define the regions of the HIV genome necessary for viral replication in the laboratory of Patrick O. Brown, M.D. / Ph.D. As a clinical fellow, she worked with Jeanne Loring, Ph.D. at The Scripps Research Institute to delineate the expression of miRNAs in human embryonic stem cells. Her current research focuses on applying genomic and epigenomic methods to understanding the molecular regulation of pluripotency and differentiation, optimizing the preclinical and clinical utility of human pluripotent stem cells, and identifying the molecular basis of placental dysfunction in human pregnancy.

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Extracellular RNAs as Biomarkers for Placental Function and Dysfunction

Friday, 30 September 2016 at 10:00

Add to Calendar ▼2016-09-30 10:00:002016-09-30 11:00:00Europe/LondonExtracellular RNAs as Biomarkers for Placental Function and DysfunctionLiquid Biopsies and Minimally-Invasive Diagnostics 2016 in San Diego, California, USASan Diego, California,

Placental dysfunction is responsible for a large fraction of the morbidity and mortality seen in pregnancy, and includes preeclampsia and fetal growth restriction. Although the clinical manifestations of these complications arise in the second half of pregnancy, they stem from abnormal placental development during the first trimester. Therefore, we hypothesize that there are biomarkers that can be evaluated early in pregnancy that will predict later onset of clinical signs and symptoms. Building upon the knowledge that placental RNAs can be detected in the serum of pregnant women, we have used next-generation sequencing of extracellular RNA to identify candidate miRNAs for the prediction of placental dysfunction. Here, we will discuss the techniques used for generation and analysis of the data, and present results supporting the discovery and validation of these biomarkers.

Add to Calendar ▼2016-09-29 00:00:002016-09-30 00:00:00Europe/LondonLiquid Biopsies and Minimally-Invasive Diagnostics 2016Liquid Biopsies and Minimally-Invasive Diagnostics 2016 in San Diego, California, USASan Diego, California,