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SELECTBIO Conferences Innovations in Microfluidics 2020

Shulamit Levenberg's Biography

Shulamit Levenberg, Professor and Dean, Faculty of Biomedical Engineering, Technion Israel Institute of Technology

Professor Shulamit Levenberg is the elected Dean of the Biomedical Engineering Department at the Technion. She also serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Prof Levenberg earned her PhD at the Weizmann Institute of Science, where she focused on cell adhesion dynamics and signaling, and pursued her post-doctoral research in tissue engineering at MIT, in the lab of Professor Robert Langer. In 2004, she joined the Technion Faculty of Biomedical Engineering where she conducts interdisciplinary research on stem cells and tissue engineering. She spent a sabbatical year (2011-2012) as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical (2017) at the University of Western Australia as a winner of the Raine Visiting Professor Award. Prof Levenberg received the Krill Prize for excellence in scientific research, awarded by the Wolf Foundation, and was named by Scientific American as a “Research Leader” in tissue engineering, for her seminal work on vascularization of engineered tissues. She also received the France-Israel Foundation Prize, the Italian Excellence for Israel Prize, the Teva Research Prize and the Juludan Prize. In 2018, she received the Rappaport Prize for Biomedical Sciences. Levenberg has authored over 100 publications, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and CSO of two start-up companies in the areas of cultured meat and nanoliter arrays for rapid antimicrobial susceptibility testing. She is a member of the Israel National Counsel for Bioethics and is actively involved in training young scientists.

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Engineering Printable 3D Vascularized Tissue Constructs

Monday, 17 August 2020 at 11:30

Add to Calendar ▼2020-08-17 11:30:002020-08-17 12:30:00Europe/LondonEngineering Printable 3D Vascularized Tissue Constructs Innovations in Microfluidics 2020 in Boston, USABoston,

Living tissues require a vascular network to supply nutrients and gases and remove cellular waste. Fabricating vascularized constructs represents a key challenge in tissue engineering. Several methods have been proposed to create in vitro pre-vascularized tissues, including co-culturing of endothelial cells, support cells and cells specific to the tissue of interest. This approach supports formation of endothelial vessels and promotes endothelial and tissue-specific cell interactions. In addition, we have shown that in vitro pre-vascularization of engineered tissue can promote its survival and perfusion upon implantation.  Implanted vascular networks, can anastomose with host vasculature and form functional blood vessels in vivo. Sufficient vascularization in engineered tissues can be achieved through coordinated application of improved biomaterial systems with proper cell types. We have shown that vessel network maturity levels and morphology are highly regulated by matrix composition. We also explored the effect of mechanical forces on vessels organization and analyzed the vasculogenic dynamics within the constructs. We demonstrated that morphogenesis of 3D vascular networks is highly regulated by tensile forces.  Creating complex vascular networks with varying vessel sizes is the next challenge in engineering vascularized tissue constructs. 3D bioprinting, the controlled and automatized deposition of biomaterials and cells, represents a very attractive approach to solve this issue. This technique allows for combining different bioinks (biocompatible printable materials) in an organized fashion to attain native-tissue mimicking structures.

Add to Calendar ▼2020-08-17 00:00:002020-08-18 00:00:00Europe/LondonInnovations in Microfluidics 2020Innovations in Microfluidics 2020 in Boston, USABoston,