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SELECTBIO Conferences ADME & Predictive Toxicology Europe

Mark Cronin's Biography

Mark Cronin, Professor, Liverpool John Moores University

Mark Cronin is Professor of Predictive Toxicology at the School of Pharmacy and Chemistry, Liverpool John Moores University (LJMU), Liverpool, England. At LJMU Mark Cronin currently leads research into the area of quantitative structure-activity relationships (QSARs) with a particular emphasis towards predicting the toxicity of chemicals. Mark Cronin has over 20 years expertise in the application of quantitative structure-activity relationships (QSARs) to predict the toxicity and fate of chemicals and drugs; in addition to development of strategies (such as integrated testing strategies) to develop alternatives to whole animal testing for toxicity. The alternatives include the whole range of in silico techniques (use of existing data; (Q)SARs; expert systems), data from chemical reactivity (in chemico) assays; and data from in vitro techniques. Research in recent years has centred on the application of these alternatives for regulatory use and for product development. This research effort has resulted in over 170 publications in all areas of the use of (Q)SARs and expert systems to predict toxicity including three books. Current projects include the activities towards the development of the OECD (Q)SAR Application Toolbox, the OSIRIS and eTox EU projects, co-ordinator of the Defra-LINK Alternatives Project, as well as many collaborations with industry and regulatory agencies. Mark has served on a number of national and international committees including those for the OECD, ECVAM and ECB.

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Rationalising Reactive Toxicity: From Chemistry to Adverse Effects

Tuesday, 13 March 2012 at 11:45

Add to Calendar ▼2012-03-13 11:45:002012-03-13 12:45:00Europe/LondonRationalising Reactive Toxicity: From Chemistry to Adverse EffectsADME and Predictive Toxicology Europe in Munich, GermanyMunich,

Many drug toxicities are brought about through reactive metabolites. The chemistry associated with reactivity will be described and will allow for the prediction of adverse effects and systemic toxicity.

Add to Calendar ▼2012-03-13 00:00:002012-03-14 00:00:00Europe/LondonADME and Predictive Toxicology EuropeADME and Predictive Toxicology Europe in Munich, GermanyMunich,