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SELECTBIO Conferences Point-of-Care Diagnostics World Congress

Kevin Plaxco's Biography

Kevin Plaxco, Professor, University of California-Santa Barbara

Dr. Kevin Plaxco is a chemistry Professor at the University of California Santa Barbara, where he serves as the Associate Director for the Center for Bioengineering. Dr. Plaxco's research focus is on the physics of biomolecular folding and its engineering applications in biosensors and responsive materials. In particular, Dr. Plaxco's group has demonstrated exceptionally robust probe designs for nucleic acid recognition, which work in a range of different sample environments such as soil and whole blood. Dr. Plaxco has co-authored numerous biosensor patents, more than 165 papers on protein folding, protein dynamics and folding-based sensors, and a popular textbook on astrobiology and the origins of life.

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E-DNA: A Versatile Electrochemical Platform for Point-of-Care Molecular Measurement

Thursday, 18 September 2014 at 14:00

Add to Calendar ▼2014-09-18 14:00:002014-09-18 15:00:00Europe/LondonE-DNA: A Versatile Electrochemical Platform for Point-of-Care Molecular MeasurementPoint-of-Care Diagnostics World Congress in San Diego, California, USASan Diego, California,

The ideal sensor will be sensitive, specific, versatile, small enough to hold in your hand, and selective enough to work even when faced with complex, contaminant-ridden samples. Given the affinity, specificity and generalizability of biomolecular recognition, biosensors have been widely touted for their potential to meet these challenging goals. To date, however, the translation of protein- and nucleic acid-binding events into convenient, highly selective sensing platforms has proven problematic. We have solved this problem by employing the ligand-induced folding of biopolymers as a robust means of transducing binding events into specific, easily detected outputs. Our electronic, folding-based sensors are rapid (minutes to seconds), sensitive (micromolar to femtomolar), and generalizable to an enormous range of protein, nucleic acid and small molecule targets. The sensors are also reagentless, reusable, and selective enough to be employed in blood serum, soil and other grossly contaminated samples. Because of their sensitivity, background suppression, operational convenience and impressive scalability folding-based biosensors appear ideally suited for diagnostics at the point of care and in the developing world.

Add to Calendar ▼2014-09-18 00:00:002014-09-19 00:00:00Europe/LondonPoint-of-Care Diagnostics World CongressPoint-of-Care Diagnostics World Congress in San Diego, California, USASan Diego, California,