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SELECTBIO Conferences Stem Cells for Drug Discovery & Toxicity Screening 2017

Daniele Zink's Biography

Daniele Zink, Principal Research Scientist and Team Leader, Institute of Bioengineering and Nanotechology, Agency for Science Technology and Research (A*STAR)

Daniele Zink studied Biology at the University of Bielefeld (Germany) and earned her PhD from the University of Heidelberg in 1995 where she worked in the fields of developmental biology and epigenetics. After becoming a postdoctoral fellow at the Institute of Human Genetics of the University of Heidelberg, she was appointed in 1996 as Research Assistant Professor at the Institute of Anthropology and Human Genetics of the Ludwig-Maximilians University (LMU) of Munich, Germany, where she completed her Habilitation in Cell Biology in 2001. In 2001, she was awarded a grant from the Volkswagen-Foundation for the funding of a Junior Group. She was head of the Junior Group located at the LMU (Department of Biology II) until she moved to the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research, Singapore in 2007, as Team Leader and Principal Research Scientist. Her research at IBN focuses on the development of predictive models for in vitro toxicology/nanotoxicology. In addition, she performs research on stem cells, which is directed towards applications in predictive toxicology and the development of cost-effective fully synthetic cultivation systems for industrial applications. The work on predictive in vitro models has been awarded by the US Society of Toxicology in 2015 and has won the prestigious LUSH Prize (2016, Science Category). The predictive in vitro models are used in collaboration with the US Environmental Protection Agency for the prediction of the human nephrotoxicity of ToxCast compounds. Zink holds 12 patents/patent applications, is Editorial Board Member of Scientific Reports and has > 70 publications, which include publications in Nature, Nature Reviews Cancer, Archives of Toxicology and Nanotoxicology.

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Stem Cell-Based Screening Platforms for the Efficient and Accurate Prediction of Nephrotoxicity in Humans

Tuesday, 11 July 2017 at 09:30

Add to Calendar ▼2017-07-11 09:30:002017-07-11 10:30:00Europe/LondonStem Cell-Based Screening Platforms for the Efficient and Accurate Prediction of Nephrotoxicity in HumansStem Cells for Drug Discovery and Toxicity Screening 2017 in Boston, USABoston,

The presentation will summarize our work on stem cell-based screening platforms for the prediction of nephrotoxicity, and in particular renal proximal tubular toxicity, in humans. Our most advanced technology is based induced pluripotent stem cells (iPSC), which are differentiated by the currently most rapid and efficient protocol into renal proximal tubular-like cells ( Kandasamy et al., 2015). In combination with one of our recently established in vitro methods for nephrotoxicity prediction (Li et al., 2013; 2014) and machine learning (Su et al., 2014), an iPSC-based platform has been developed that predicts proximal tubular cell toxicity in humans with 87% test balanced accuracy (Kandasamy et al., 2015). Our iPSC-based technologies are compatible with our high-throughput platform for nephrotoxicity prediction (Su et al., 2015), and we are currently exploring predictive kidney-on-a-chip approaches.

Add to Calendar ▼2017-07-10 00:00:002017-07-11 00:00:00Europe/LondonStem Cells for Drug Discovery and Toxicity Screening 2017Stem Cells for Drug Discovery and Toxicity Screening 2017 in Boston, USABoston,