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SELECTBIO Conferences Biodetection & Biosensors 2017

Martyn Boutelle's Biography



Martyn Boutelle, Professor of Biomedical Sensors Engineering, Vice Chair Department of Bioengineering, Imperial College London

After an initial undergraduate training in Chemistry and a PhD in Electrochemistry at Imperial College London. I worked as a research fellow in the University Laboratory of Physiology, University of Oxford using implantable electrochemical sensors and microdialysis probes to study brain neurochemistry. This work was extended to clinical monitoring of the injured brain when I moved to the Department of Chemistry, King’s College London. I moved to the Department of Bioengineering at Imperial College in 2004. My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods, particularly combining microfluidic devices with electrochemical sensors, and the use of these new techniques in a program of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

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Biosensors, Sensors and Microfluidic Devices – Key Technologies to Enable Real-Time Patient Monitoring and Treatment

Tuesday, 10 October 2017 at 12:15

Add to Calendar ▼2017-10-10 12:15:002017-10-10 13:15:00Europe/LondonBiosensors, Sensors and Microfluidic Devices – Key Technologies to Enable Real-Time Patient Monitoring and TreatmentBiodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com

Clinical practice is beginning to wake upto the potential of real-time molecular information from venerable tissue as a means to understand the progression in the tissue of injury or disease. Such patterns of molecular changes, particularly when combined with paternal of physical of electrical signatures, offer the exciting possibility of allowing clinicians to guide therapy on an individualized basis in real time. Microfluidic lab-on-chip devices coupled to tissue sampling using microdialysis provide an important new way for measuring real-time chemical changes as the low volume flow rates of microdialysis probes are ideally matched to the length scales of microfluidic devices. In this presentation I will describe the combination of miniature electrochemical sensors and biosensors with 3D printed microfluidic devices for transplant organ and patient monitoring. Concentrations of key biomarker molecules can then be determined continuously using either optically or electrochemically, using amperometric, potentiometic and array sensors.  Wireless devices allow analysis to take place close to the patient. Droplet-based microfluidics, by digitizing the dialysis stream into discrete low volume samples, both minimizes dispersion allowing very rapid concentration changes to be measured, and allows rapid transport of samples between patient and analysis chip. This talk will overview successful design, optimization, automatic-calibration and use of both continuous flow and droplet-based microfluidic analysis systems for real-time clinical monitoring, using clinical examples from our recent work.


Add to Calendar ▼2017-10-10 00:00:002017-10-11 00:00:00Europe/LondonBiodetection and Biosensors 2017Biodetection and Biosensors 2017 in Murray Edwards College, Cambridge, UKMurray Edwards College, Cambridge, UKSELECTBIOenquiries@selectbiosciences.com