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SELECTBIO Conferences Lab-on-a-Chip, Microfluidics & Microarrays World Congress 2016

Martyn Boutelle's Biography



Martyn Boutelle, Professor of Biomedical Sensors Engineering, Vice Chair Department of Bioengineering, Imperial College London

After an initial undergraduate training in Chemistry and a PhD in Electrochemistry at Imperial College London. I worked as a research fellow in the University Laboratory of Physiology, University of Oxford using implantable electrochemical sensors and microdialysis probes to study brain neurochemistry. This work was extended to clinical monitoring of the injured brain when I moved to the Department of Chemistry, King’s College London. I moved to the Department of Bioengineering at Imperial College in 2004. My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods, particularly combining microfluidic devices with electrochemical sensors, and the use of these new techniques in a program of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

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Microfluidics and Sensors: New Tools for Real-Time Clinical Monitoring

Monday, 26 September 2016 at 16:30

Add to Calendar ▼2016-09-26 16:30:002016-09-26 17:30:00Europe/LondonMicrofluidics and Sensors: New Tools for Real-Time Clinical MonitoringLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

A goal for modern medicine is to protect vulnerable tissue by monitoring the patterns of changing physical,  electrical and chemical changes taking place in tissue - ‘multimodal monitoring’. Clinicians hope such information will allows treatments to be guided and ultimately controlled based on the measured signals. Microfluidic lab-on-chip devices coupled to tissue sampling using microdialysis provide an important new way for measuring real-time chemical changes as the low volume flow rates  of microdialysis probes are ideally matched to the length scales of microfluidic devices. Concentrations of key biomarker molecules can then be determined continuously using either optically or electrochemically (using amperometric, and potentiometic sensors).  Wireless devices allow analysis to take place close to the patient. Droplet-based microfluidics, by digitizing the dialysis stream into discrete low volume samples, both minimizes dispersion allowing very rapid concentration changes to be measured, and allows rapid transport of samples between patient and analysis chip. This talk will overview successful design, optimization, automatic-calibration and use of both continuous flow and droplet-based microfluidic analysis systems for real-time clinical monitoring, using clinical examples from our recent work.

Microfluidics and Sensors: New Tools for Real-Time Clinical Monitoring

Monday, 26 September 2016 at 16:30

Add to Calendar ▼2016-09-26 16:30:002016-09-26 17:30:00Europe/LondonMicrofluidics and Sensors: New Tools for Real-Time Clinical MonitoringLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com

A goal for modern medicine is to protect vulnerable tissue by monitoring the patterns of changing physical,  electrical and chemical changes taking place in tissue - ‘multimodal monitoring’. Clinicians hope such information will allows treatments to be guided and ultimately controlled based on the measured signals. Microfluidic lab-on-chip devices coupled to tissue sampling using microdialysis provide an important new way for measuring real-time chemical changes as the low volume flow rates  of microdialysis probes are ideally matched to the length scales of microfluidic devices. Concentrations of key biomarker molecules can then be determined continuously using either optically or electrochemically (using amperometric, and potentiometic sensors).  Wireless devices allow analysis to take place close to the patient. Droplet-based microfluidics, by digitizing the dialysis stream into discrete low volume samples, both minimizes dispersion allowing very rapid concentration changes to be measured, and allows rapid transport of samples between patient and analysis chip. This talk will overview successful design, optimization, automatic-calibration and use of both continuous flow and droplet-based microfluidic analysis systems for real-time clinical monitoring, using clinical examples from our recent work.


Add to Calendar ▼2016-09-26 00:00:002016-09-28 00:00:00Europe/LondonLab-on-a-Chip, Microfluidics and Microarrays World Congress 2016Lab-on-a-Chip, Microfluidics and Microarrays World Congress 2016 in San Diego, California, USASan Diego, California, USASELECTBIOenquiries@selectbiosciences.com