Martyn Boutelle,
Professor of Biomedical Sensors Engineering,
Imperial College London
Martyn Boutelle is Professor of Biomedical Sensors Engineering in the Department of Bioengineering, Imperial College London, and Associate Provost for Estates Planning for Imperial College. His research group is multidisciplinary comprising, bioengineers, scientists, and clinicians. He develops novel analytical science methods using microfluidics, electrochemical sensors / biosensors, and wireless electronics to make portable (sometimes wearable) monitoring devices for use as point of care devices that typically giving continuous real -time displays. He then uses these in a program of clinical science research focusing on the acute traumatic brain injury including that caused by cardiac arrest, neonatal continuous monitoring and kidney transplantation monitoring. He runs the EPSRC funded Bio-nanofabrication suite designed to make microfluidic and biosensor biosensors using scalable methods to allow use in proof-of-concept clinical trials.
Martyn is past president of the International Society for Monitoring Molecules in Neuroscience, and a founder of the COSBID organization for studying acute human brain injury. He published > 190 papers, chapters and patents. He obtained a BSc and PhD in Chemistry from Imperial College and worked as an EP Abraham Research Fellow in the University of Oxford.
Towards Wearable Real-Time Clinical Monitoring Using Microfluidic Devices
Tuesday, 5 June 2018 at 09:00
Add to Calendar ▼2018-06-05 09:00:002018-06-05 10:00:00Europe/LondonTowards Wearable Real-Time Clinical Monitoring Using Microfluidic DevicesOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Modern acute critical care medicine is increasingly seeking to protect
vulnerable tissue from damage by monitoring the patterns of physical,
electrical and chemical changes taking place in tissue – so called
multimodal monitoring. Such patterns of molecular changes offer the
exciting possibility of allowing clinicians to detect changes in patient
condition and to guide therapy on an individualized basis in real time.
Microfluidic lab-on-chip devices coupled to tissue sampling using
microdialysis provide an important new way for measuring real-time
chemical changes as the low volume flow rates of microdialysis probes
are ideally matched to the length scales of microfluidic devices. In
this presentation, I will describe the combination of miniature
electrochemical sensors and biosensors with 3D printed microfluidic
devices for transplant organ and patient monitoring. Concentrations of
key biomarker molecules can then be determined continuously using either
optically or electrochemically, using amperometric, potentiometic and
array sensors. Wireless devices allow analysis to take place close to
the patient. Droplet-based microfluidics, by digitizing the dialysis
stream into discrete low volume samples, both minimizes dispersion
allowing very rapid concentration changes to be measured, and allows
rapid transport of samples between patient and analysis chip. This talk
will overview successful design, optimization, automatic-calibration and
use of both continuous flow and droplet-based microfluidic analysis
systems for real-time clinical monitoring, using clinical examples from
our recent work.
Add to Calendar ▼2018-06-05 00:00:002018-06-06 00:00:00Europe/LondonOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018Organ-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
Add to Calendar ▼2018-06-05 09:00:002018-06-05 10:00:00Europe/LondonTowards Wearable Real-Time Clinical Monitoring Using Microfluidic DevicesOrgan-on-a-Chip, Tissue-on-a-Chip Europe 2018 in Rotterdam, The NetherlandsRotterdam, The NetherlandsSELECTBIOenquiries@selectbiosciences.com
