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SELECTBIO Conferences Next-Gen Sequencing

Wenzhong Xiao's Biography

Wenzhong Xiao, Assistant Professor, Massachusetts General Hospital

Wenzhong Xiao directs the Human Systems Biology Laboratory at Massachusetts General Hospital and the Computational Biology Group at Stanford Genome Technology Center. He also oversees the data analysis for the NIGMS Inflammation and the Host Response to Injury Glue Grant consortium. His research interests include developing genomic tools and computational methods for high-throughput genomics and proteomics analysis and applications in clinical studies.

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Computational Analysis of Human Immune Repertoire

Thursday, 19 April 2012 at 11:15

Add to Calendar ▼2012-04-19 11:15:002012-04-19 12:15:00Europe/LondonComputational Analysis of Human Immune Repertoire

The immune repertoire of an individual is the collection of antigen receptors of B or T cells generated by rearrangements of V(D)J gene segments and somatic hypermutations in response to pathogens as well as autoantigens. High-throughput sequencing (HTS) enables the comprehensive examination of the repertoire which provides important information on the body’s immune state and competency in health and disease. However, new technology inevitably comes with challenges. Sequencing errors introduced during sample processing and sequencing steps can lead to misidentification of clonotypes and artificial inflation of the diversity. Moreover, sophisticated statistical and computational approaches need to be developed to evaluate the state of the immune repertoire from the large amounts of HTS data for the diagnosis and prognosis of immunological and other related diseases. I will discuss the testing experiments and computational algorithms to improve the accuracy of identifying low frequency clonotypes (i.e. somatic hypermutations), as well as the statistical approaches we developed to model the molecular evolution of the immune repertoire for disease detection and monitoring.

Add to Calendar ▼2012-04-19 00:00:002012-04-20 00:00:00Europe/LondonNext-Gen