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SELECTBIO Conferences Lab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and Applications

Charles Henry's Biography

Charles Henry, Professor and Chair, Colorado State University

Charles Henry is a Professor in and Chair of the Chemistry Department at Colorado State University. He also holds appointments in Chemical & Biological Engineering and Biomedical Engineering. Work in the Henry group focuses on the application of microfluidics to environmental and occupational exposure monitoring, measurement of chemical gradients in biology, and development of low cost, point of need measurement systems.

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Instrumented Tissue-in-a-Chip: A Bridge from In Vitro to In Vivo

Tuesday, 3 October 2017 at 10:00

Add to Calendar ▼2017-10-03 10:00:002017-10-03 11:00:00Europe/LondonInstrumented Tissue-in-a-Chip: A Bridge from In Vitro to In

Microfluidic methods provide a promising path to mimicking human organ function with applications ranging from fundamental biology to drug metabolism and toxicity. The vast majority of these systems use dissociated, immortalized, or stem cells to create two and three-dimensional models in vitro. While these systems can provide valuable information, they are fundamentally incapable of recreating the three-dimensional complexity of real tissue. As a result, an important gap exists between in vitro models and in vivo systems. To address this gap, we have created instrumented Tissue-In-a-Chip (iTIC) system that combines microfluidic devices with ex vivo tissue slices or explants to recreate model systems that capture the cellular diversity of real tissue and bridge the gap between in vitro models and in vivo systems. In this presentation two systems will be discussed. The first uses a high-density electrode array equipped with microfluidic flow to image chemical release profiles from living adrenal slices. The second uses a 3D printed microfluidic device with removable inserts to hold and perfuse fluids over intestinal tissue, enabling generation of differential chemical conditions on either side of this important barrier tissue.

Add to Calendar ▼2017-10-02 00:00:002017-10-04 00:00:00Europe/LondonLab-on-a-Chip and Microfluidics: Emerging Themes, Technologies and